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8TND
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BU of 8tnd by Molmil
De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - holo veliparib
分子名称: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, De novo designed protein, SULFATE ION
著者Lu, L, DeGrado, W.F.
登録日2023-08-01
公開日2024-04-24
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献De novo design of drug-binding proteins with predictable binding energy and specificity.
Science, 384, 2024
9NKF
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BU of 9nkf by Molmil
Structure of human substrate-free 26S proteasome in the presence of ATPgS and MG-132,SA-like state (composite map)
分子名称: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ...
著者Peddada, N, Beutler, B.
登録日2025-02-28
公開日2025-05-07
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the ubiquitin-independent midnolin-proteasome pathway.
Proc.Natl.Acad.Sci.USA, 122, 2025
9NKG
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BU of 9nkg by Molmil
Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)
分子名称: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ...
著者Peddada, N, Beutler, B.
登録日2025-02-28
公開日2025-05-07
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural insights into the ubiquitin-independent midnolin-proteasome pathway.
Proc.Natl.Acad.Sci.USA, 122, 2025
9NKI
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BU of 9nki by Molmil
Structure of substrate engaged MIDN-bound human 26S proteasome, EB MIDN_UBL state (Composite map)
分子名称: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ...
著者Peddada, N, Beutler, B.
登録日2025-02-28
公開日2025-05-07
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural insights into the ubiquitin-independent midnolin-proteasome pathway.
Proc.Natl.Acad.Sci.USA, 122, 2025
9NKJ
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BU of 9nkj by Molmil
Structure of substrates-engaged MIDN-bound human 26S proteasome,ED-MIDN state (Composite map)
分子名称: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ...
著者Peddada, N, Beutler, B.
登録日2025-02-28
公開日2025-05-07
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献Structural insights into the ubiquitin-independent midnolin-proteasome pathway.
Proc.Natl.Acad.Sci.USA, 122, 2025
3GAC
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BU of 3gac by Molmil
Structure of mif with HPP
分子名称: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ACETIC ACID, Macrophage migration inhibitory factor-like protein, ...
著者Zhou, Y.-F, Su, X.-D, Shao, D, Wang, H.
登録日2009-02-17
公開日2009-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host
Mol.Immunol., 47, 2010
3GAD
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BU of 3gad by Molmil
Structure of apomif
分子名称: ACETIC ACID, Macrophage migration inhibitory factor-like protein, SULFATE ION
著者Zhou, Y.-F, Su, X.-D, Shao, D, Wang, H.
登録日2009-02-17
公開日2009-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host
Mol.Immunol., 47, 2010
2RJQ
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BU of 2rjq by Molmil
Crystal structure of ADAMTS5 with inhibitor bound
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, ADAMTS-5, ...
著者Mosyak, L, Stahl, M, Somers, W.
登録日2007-10-15
公開日2007-12-11
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
2RJP
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BU of 2rjp by Molmil
Crystal structure of ADAMTS4 with inhibitor bound
分子名称: ADAMTS-4, CALCIUM ION, N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}sulfonyl)-D-valine, ...
著者Mosyak, L, Stahl, M, Somers, W.
登録日2007-10-15
公開日2007-12-11
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
7UBU
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BU of 7ubu by Molmil
Crystal structure of ZMET2 in complex with hemimethylated CAG DNA and a histone H3Kc9me2 peptide
分子名称: 5MC SSDNA, C49 SSDNA, DNA (cytosine-5)-methyltransferase 1, ...
著者Fang, J, Song, J.
登録日2022-03-15
公開日2022-06-08
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Mechanistic basis for maintenance of CHG DNA methylation in plants.
Nat Commun, 13, 2022
8T1U
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BU of 8t1u by Molmil
Crystal structure of the DRM2-CTA DNA complex
分子名称: DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ...
著者Chen, J, Lu, J, Song, J.
登録日2023-06-03
公開日2023-11-22
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2.
J.Biol.Chem., 299, 2023
8H10
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BU of 8h10 by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-2 Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ...
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-10-19
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H13
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BU of 8h13 by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x2 Disulfide (G400C and V969C), Closed Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-10-19
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (4.05 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H14
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BU of 8h14 by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x3 Disulfide (D414C and V969C), Locked-1 Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, Spike glycoprotein
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-10-19
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H16
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BU of 8h16 by Molmil
Structure of SARS-CoV-1 Spike Protein (S/native) at pH 5.5, Open Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.35534 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H11
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BU of 8h11 by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Closed Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (2.72 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H12
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BU of 8h12 by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x2 Disulfide (G400C and V969C), Locked-2 Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.44681 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H15
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BU of 8h15 by Molmil
Structure of SARS-CoV-1 Spike Protein (S/native) at pH 5.5, Closed Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (3.14182 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H0X
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BU of 8h0x by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-1 Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, LINOLEIC ACID, ...
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
8H0Y
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BU of 8h0y by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-112 Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, LINOLEIC ACID, ...
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
3B2Z
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BU of 3b2z by Molmil
Crystal Structure of ADAMTS4 (apo form)
分子名称: ADAMTS-4, CALCIUM ION, ZINC ION
著者Mosyak, L, Stahl, M, Somers, W.
登録日2007-10-19
公開日2007-12-25
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
5Z8L
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BU of 5z8l by Molmil
crystal structure of Arabidopsis thaliana EBS in complex with an H3K27me3 peptide
分子名称: Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION
著者Yang, Z, Du, J.
登録日2018-01-31
公開日2018-07-25
最終更新日2025-04-09
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
4NJ5
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BU of 4nj5 by Molmil
Crystal structure of SUVH9
分子名称: Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9, ZINC ION
著者Du, J, Patel, D.J.
登録日2013-11-08
公開日2014-01-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.
Nature, 507, 2014
5Z8N
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BU of 5z8n by Molmil
Crystal structure of Arabidopsis thaliana EBS C-terminal deletion construct in complex with an H3K4me2 peptide
分子名称: Chromatin remodeling protein EBS, H3K4me2 peptide, ZINC ION
著者Yang, Z, Du, J.
登録日2018-01-31
公開日2018-07-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
7L4C
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BU of 7l4c by Molmil
Crystal structure of the DRM2-CTT DNA complex
分子名称: DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ...
著者Fang, J, Song, J.
登録日2020-12-18
公開日2021-08-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021

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件を2025-07-09に公開中

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