2DJ5
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![BU of 2dj5 by Molmil](/molmil-images/mine/2dj5) | Crystal Structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus | 分子名称: | GLYCEROL, PHOSPHATE ION, Sirohydrochlorin cobaltochelatase | 著者 | Yin, J, Cherney, M.M, James, M.N.G. | 登録日 | 2006-03-31 | 公開日 | 2006-09-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal Structure of the Vitamin B(12) Biosynthetic Cobaltochelatase, CbiX (S), from Archaeoglobus Fulgidus J.STRUCT.FUNCT.GENOM., 7, 2006
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2CXV
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![BU of 2cxv by Molmil](/molmil-images/mine/2cxv) | Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-Derived betaLactone: Selective Crystallization and High-resolution Structure of the His-102 Adduct | 分子名称: | N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Probable protein P3C | 著者 | Yin, J, Bergmann, E.M, Cherney, M.M, Lall, M.S, Jain, R.P, Vederas, J.C, James, M.N.G. | 登録日 | 2005-07-01 | 公開日 | 2005-12-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-derived beta-Lactone: Selective Crystallization and Formation of a Functional Catalytic Triad in the Active Site J.MOL.BIOL., 354, 2005
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3FHA
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![BU of 3fha by Molmil](/molmil-images/mine/3fha) | Structure of endo-beta-N-acetylglucosaminidase A | 分子名称: | CALCIUM ION, Endo-beta-N-acetylglucosaminidase, GLYCEROL, ... | 著者 | Yin, J, Li, L, Shaw, N, Li, Y, Song, J.K, Zhang, W, Xia, C, Zhang, R, Joachimiak, A, Zhang, H.C, Wang, L.X, Wang, P, Liu, Z.J. | 登録日 | 2008-12-09 | 公開日 | 2009-04-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A. Plos One, 4, 2009
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7SR8
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![BU of 7sr8 by Molmil](/molmil-images/mine/7sr8) | Molecular mechanism of the the wake-promoting agent TAK-925 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | 著者 | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | 登録日 | 2021-11-08 | 公開日 | 2022-06-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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1NAU
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![BU of 1nau by Molmil](/molmil-images/mine/1nau) | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles | 分子名称: | Glucagon | 著者 | Ying, J, Ahn, J.-M, Jacobsen, N.E, Brown, M.F, Hruby, V.J. | 登録日 | 2002-11-28 | 公開日 | 2003-03-18 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles Biochemistry, 42, 2003
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6XFP
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![BU of 6xfp by Molmil](/molmil-images/mine/6xfp) | Crystal Structure of BRAF kinase domain bound to Belvarafenib | 分子名称: | 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide, CHLORIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Yin, J, Sudhamsu, J. | 登録日 | 2020-06-16 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. Nature, 594, 2021
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6XLO
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![BU of 6xlo by Molmil](/molmil-images/mine/6xlo) | Crystal structure of bRaf in complex with inhibitor | 分子名称: | 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide, IODIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Yin, J, Eigenbrot, C, Wang, W. | 登録日 | 2020-06-28 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | 主引用文献 | Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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7YPQ
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![BU of 7ypq by Molmil](/molmil-images/mine/7ypq) | Cryo-EM structure of one baculovirus LEF-3 molecule in complex with ssDNA | 分子名称: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), Lef3 | 著者 | Fu, Y, Rao, G, Yin, J, Li, Z, Cao, S. | 登録日 | 2022-08-04 | 公開日 | 2023-01-25 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural transitions during the cooperative assembly of baculovirus single-stranded DNA-binding protein on ssDNA. Nucleic Acids Res., 50, 2022
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4XJ0
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![BU of 4xj0 by Molmil](/molmil-images/mine/4xj0) | Crystal structure of ERK2 in complex with an inhibitor 14K | 分子名称: | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1 | 著者 | Yin, J, Wang, W. | 登録日 | 2015-01-08 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J.Med.Chem., 58, 2015
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5K4J
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![BU of 5k4j by Molmil](/molmil-images/mine/5k4j) | Crystal Structure of CDK2 in complex with compound 22 | 分子名称: | 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Cyclin-dependent kinase 2 | 著者 | Yin, J, Wang, W. | 登録日 | 2016-05-20 | 公開日 | 2016-07-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem., 59, 2016
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5K4I
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![BU of 5k4i by Molmil](/molmil-images/mine/5k4i) | Crystal Structure of ERK2 in complex with compound 22 | 分子名称: | 1,2-ETHANEDIOL, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Mitogen-activated protein kinase 1 | 著者 | Yin, J, Wang, W. | 登録日 | 2016-05-20 | 公開日 | 2016-07-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem., 59, 2016
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4QP1
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![BU of 4qp1 by Molmil](/molmil-images/mine/4qp1) | |
4QP9
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![BU of 4qp9 by Molmil](/molmil-images/mine/4qp9) | |
4QP7
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![BU of 4qp7 by Molmil](/molmil-images/mine/4qp7) | |
4QP4
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![BU of 4qp4 by Molmil](/molmil-images/mine/4qp4) | |
4QPA
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![BU of 4qpa by Molmil](/molmil-images/mine/4qpa) | |
4QP3
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![BU of 4qp3 by Molmil](/molmil-images/mine/4qp3) | |
4QP6
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![BU of 4qp6 by Molmil](/molmil-images/mine/4qp6) | |
4QP8
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![BU of 4qp8 by Molmil](/molmil-images/mine/4qp8) | |
4QP2
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![BU of 4qp2 by Molmil](/molmil-images/mine/4qp2) | |
7RCO
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![BU of 7rco by Molmil](/molmil-images/mine/7rco) | |
7U5B
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![BU of 7u5b by Molmil](/molmil-images/mine/7u5b) | |
7K0V
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![BU of 7k0v by Molmil](/molmil-images/mine/7k0v) | Crystal structure of bRaf in complex with inhibitor GNE-0749 | 分子名称: | CHLORIDE ION, N-(3,3-dimethylbutyl)-N'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea, Non-specific serine/threonine protein kinase | 著者 | Yin, J, Eigenbrot, C.E, Wang, W. | 登録日 | 2020-09-06 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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6D5Y
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3TMO
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![BU of 3tmo by Molmil](/molmil-images/mine/3tmo) | The catalytic domain of human deubiquitinase DUBA | 分子名称: | OTU domain-containing protein 5 | 著者 | Yin, J, Bosanac, I, Ma, X, Hymowitz, S, Starovasnik, M, Cochran, A. | 登録日 | 2011-08-31 | 公開日 | 2012-01-11 | 最終更新日 | 2012-02-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat.Struct.Mol.Biol., 19, 2012
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