6TXH
 
 | | Crystal structure of thermotoga maritima Ferritin in apo form | | 分子名称: | EICOSANE, Ferritin, GLYCEROL, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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6TXL
 | | Crystal structure of thermotoga maritima E65Q Ferritin | | 分子名称: | EICOSANE, FE (III) ION, Ferritin, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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6TXN
 | | Crystal structure of thermotoga maritima Ferritin in apo form | | 分子名称: | EICOSANE, Ferritin, GLYCEROL, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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6TXM
 | | Crystal structure of thermotoga maritima E65R Ferritin | | 分子名称: | EICOSANE, Ferritin, GLYCEROL, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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6TXJ
 | | Crystal structure of thermotoga maritima A42V E65D Ferritin | | 分子名称: | EICOSANE, FE (III) ION, Ferritin, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S, Biela, A.P. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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6TXK
 | | Crystal structure of thermotoga maritima E65K Ferritin | | 分子名称: | EICOSANE, FE (III) ION, Ferritin, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.359 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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6TXI
 | | Crystal structure of thermotoga maritima E65A Ferritin | | 分子名称: | EICOSANE, FE (III) ION, Ferritin, ... | | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | | 登録日 | 2020-01-14 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.759 Å) | | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin.
Nanoscale, 13, 2021
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4PSG
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7PQ7
 | | Crystal structure of Campylobacter jejuni DsbA1 | | 分子名称: | TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, Thiol:disulfide interchange protein DsbA | | 著者 | Wilk, P, Orlikowska, M, Banas, A.M, Bocian-Ostrzycka, K.M, Jagusztyn-Krynicka, E.K. | | 登録日 | 2021-09-16 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Interplay between DsbA1, DsbA2 and C8J_1298 Periplasmic Oxidoreductases of Campylobacter jejuni and Their Impact on Bacterial Physiology and Pathogenesis.
Int J Mol Sci, 22, 2021
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7PQF
 | | Crystal structure of Campylobacter jejuni DsbA2 | | 分子名称: | Thiol:disulfide interchange protein DsbA/DsbL | | 著者 | Wilk, P, Banas, A.M, Bocian-Ostrzycka, K.M, Jagusztyn-Krynicka, E.K. | | 登録日 | 2021-09-17 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Interplay between DsbA1, DsbA2 and C8J_1298 Periplasmic Oxidoreductases of Campylobacter jejuni and Their Impact on Bacterial Physiology and Pathogenesis.
Int J Mol Sci, 22, 2021
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4IQB
 | | High Resolution Crystal Structure of C.elegans Thymidylate Synthase | | 分子名称: | SULFATE ION, Thymidylate synthase | | 著者 | Wilk, P, Dowiercial, A, Banaszak, K, Jarmula, A, Rypniewski, W, Rode, W. | | 登録日 | 2013-01-11 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.
J. Mol. Graph. Model., 77, 2017
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5NOO
 | | Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | | 著者 | Wilk, P, Jarmula, A, Maj, P, Dowiercial, A, Banaszak, K, Rypniewski, W, Rode, W. | | 登録日 | 2017-04-12 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.
J. Mol. Graph. Model., 77, 2017
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5M4Z
 | | Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate | | 分子名称: | GLYCEROL, Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Wilk, P, Maj, P, Jarmula, A, Dowiercial, A, Rode, W. | | 登録日 | 2016-10-19 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.179 Å) | | 主引用文献 | Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.
Int J Mol Sci, 22, 2021
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5FCT
 | | Mouse thymidylate synthase in ternary complex with FdUMP and methylenetetrahydrofolate. | | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Thymidylate synthase | | 著者 | Dowiercial, A, Wilk, P, Jarmula, A, Rode, W. | | 登録日 | 2015-12-15 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
Struct Chem, 2016
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4EZ8
 | | Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate | | 分子名称: | 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), DIHYDROFOLIC ACID, GLYCEROL, ... | | 著者 | Dowiercial, A, Jarmula, A, Rypniewski, W, Wilk, P, Kierdaszuk, B, Banaszak, K, Gorecka, K, Rode, W. | | 登録日 | 2012-05-02 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Crystal structures of complexes of mouse thymidylate synthase
crystallized with N4-OH-dCMP alone or in the presence of
N5,10-methylenetetrahydrofolate
Pteridines, 2013
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5BY6
 | | Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... | | 著者 | Dowiercial, A, Jarmula, A, Rypniewski, W, Fraczyk, T, Wilk, P, Rode, W. | | 登録日 | 2015-06-10 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.
J. Mol. Graph. Model., 77, 2017
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8P61
 | | Crystal structure of O'nyong'nyong virus capsid protease (106-256) | | 分子名称: | Capsid protein, GLYCEROL, SULFATE ION | | 著者 | Plewka, J, Chykunova, Y, Wilk, P, Sienczyk, M, Dubin, G, Pyrc, K. | | 登録日 | 2023-05-24 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Autoinhibition of suicidal capsid protease from O'nyong'nyong virus.
Int.J.Biol.Macromol., 262, 2024
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7Q68
 | | Crystal structure of Chaetomium thermophilum wild-type Ahp1 | | 分子名称: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | 著者 | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | 登録日 | 2021-11-05 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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8A0F
 | | Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, Deoxyhypusine synthase, ... | | 著者 | Wator, E, Wilk, P, Grudnik, P. | | 登録日 | 2022-05-27 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Nat Commun, 14, 2023
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8A0G
 | | Human deoxyhypusine synthase with trapped transition state | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,3-DIAMINOPROPANE, Deoxyhypusine synthase, ... | | 著者 | Wator, E, Wilk, P, Grudnik, P. | | 登録日 | 2022-05-27 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Nat Commun, 14, 2023
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8A0E
 | | CryoEM structure of DHS-eIF5A1 complex | | 分子名称: | Deoxyhypusine synthase, Eukaryotic translation initiation factor 5A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Wator, E, Wilk, P, Biela, A.P, Rawski, M, Grudnik, P. | | 登録日 | 2022-05-27 | | 公開日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Nat Commun, 14, 2023
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7Q69
 | | Crystal structure of Chaetomium thermophilum C30S Ahp1 in the pre-reaction state | | 分子名称: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | 著者 | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | 登録日 | 2021-11-05 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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7Q6A
 | | Crystal structure of Chaetomium thermophilum C30S Ahp1 in post-reaction state | | 分子名称: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | 著者 | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | 登録日 | 2021-11-05 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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7Q5N
 | | Crystal structure of Chaetomium thermophilum Ahp1-Urm1 complex | | 分子名称: | Thioredoxin domain-containing protein, Ubiquitin-related modifier 1, ZINC ION | | 著者 | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | 登録日 | 2021-11-04 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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6GKO
 | | Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, ... | | 著者 | Maj, P, Wilk, P, Jarmula, A, Weiss, M.S, Rode, W. | | 登録日 | 2018-05-21 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | | 主引用文献 | Thymidylate synthase fragment screening
To Be Published
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