4EZ8

Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate

Summary for 4EZ8

• Entry DOI: 10.2210/pdb4ez8/pdb
• Related: 4EIN
• Descriptor: Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), DIHYDROFOLIC ACID, ... (5 entities in total)
• Functional Keywords: methyltransferase, ternary complex, dihydrofolic acid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Nucleus (By similarity): P07607
• Total number of polymer chains: 1
• Total formula weight: 35951.81

Authors

Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Wilk, P.,Kierdaszuk, B.,Banaszak, K.,Gorecka, K.,Rode, W. (deposition date: 2012-05-02, release date: 2013-05-08, Last modification date: 2024-02-28)

• Primary citation: Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Wilk, P.,Kierdaszuk, B.,Banaszak, K.,Gorecka, K.,Rode, W.; Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate; Pteridines, 2013

Experimental method

X-RAY DIFFRACTION (1.17 Å)