4EZ8
Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thymidylate synthase | polymer | 307 | 35001.0 | 1 | UniProt (P07607) Pfam (PF00303) | Mus musculus (mouse) | TS, TSase |
| 2 | B (A) | 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate) | non-polymer | 323.2 | 1 | Chemie (NOH) | |||
| 3 | C (A) | DIHYDROFOLIC ACID | non-polymer | 443.4 | 1 | Chemie (DHF) | |||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F (A) | water | water | 18.0 | 478 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35001.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 950.8 | |
| All* | Total formula weight | 35951.8 |
