5FCT

Mouse thymidylate synthase in ternary complex with FdUMP and methylenetetrahydrofolate.

Summary for 5FCT

• Entry DOI: 10.2210/pdb5fct/pdb
• Related: 3IHI 4E50 4EB4 4EIN 4EZ8
• Descriptor: Thymidylate synthase, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, ... (4 entities in total)
• Functional Keywords: complex, enzyme, inhibitor, cofactor, transferase
• Biological source: Mus musculus (House Mouse)
• Total number of polymer chains: 2
• Total formula weight: 71573.29

Authors

Dowiercial, A.,Wilk, P.,Jarmula, A.,Rode, W. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2024-11-06)

• Primary citation: Dowiercial, A.,Jarmula, A.,Wilk, P.,Rypniewski, W.,Kowalska, M.,Fraczyk, T.,Ciesla, J.,Rode, W.; Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme; Struct Chem, 2016; DOI: 10.1007/s11224-016-0840-8

Experimental method

X-RAY DIFFRACTION (1.55 Å)