6KIJ
 
 | | Crystal structure of yedK with ssDNA containing an abasic site | | 分子名称: | DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), GLYCEROL, PENTANE-3,4-DIOL-5-PHOSPHATE, ... | | 著者 | Wang, N, Bao, H, Huang, H. | | 登録日 | 2019-07-18 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
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4I9O
 | | Crystal Structure of GACKIX L664C Tethered to 1-10 | | 分子名称: | 1,2-ETHANEDIOL, 1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one, CREB-binding protein | | 著者 | Wang, N, Meagher, J.L, Stuckey, J.A, Mapp, A.K. | | 登録日 | 2012-12-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Ordering a dynamic protein via a small-molecule stabilizer.
J.Am.Chem.Soc., 135, 2013
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8WWP
 | | PNPase mutant of Mycobacterium tuberculosis | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase | | 著者 | Wang, N, Sheng, Y.N, Liu, Y.T. | | 登録日 | 2023-10-26 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
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8VSP
 | | Cryo-EM structure of human invariant chain in complex with HLA-DQ | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, ... | | 著者 | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2024-01-24 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Structural insights into human MHC-II association with invariant chain.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8VRW
 | | Cryo-EM structure of human invariant chain in complex with HLA-DR15 | | 分子名称: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2024-01-22 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structural insights into human MHC-II association with invariant chain.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8WX0
 | | PNPase of M.tuberculosis with its RNA substrate | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase, RNA (24-mer) | | 著者 | Wang, N, Sheng, Y.N. | | 登録日 | 2023-10-27 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
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8WXF
 | | PNPase of Mycobacterium tuberculosis | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase | | 著者 | Wang, N, Sheng, Y.N, Liu, Y.T. | | 登録日 | 2023-10-29 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
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7EKQ
 | | CrClpP-S2c | | 分子名称: | ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic, ATP-dependent Clp protease proteolytic subunit, ... | | 著者 | Wang, N, Wang, Y.F, Cong, Y, Liu, C.M. | | 登録日 | 2021-04-06 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The cryo-EM structure of the chloroplast ClpP complex.
Nat.Plants, 7, 2021
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7EKO
 | | CrClpP-S1 | | 分子名称: | ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic, ATP-dependent Clp protease proteolytic subunit | | 著者 | Wang, N, Wang, Y.F, Cong, Y, Liu, C.M. | | 登録日 | 2021-04-06 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The cryo-EM structure of the chloroplast ClpP complex.
Nat.Plants, 7, 2021
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7CKR
 | | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation. | | 分子名称: | 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid, Basigin, Monocarboxylate transporter 1 | | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | 登録日 | 2020-07-18 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7CKO
 | | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation | | 分子名称: | 7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid, Basigin, Monocarboxylate transporter 1 | | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | 登録日 | 2020-07-18 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7DA5
 | | Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the inward-open conformation. | | 分子名称: | Basigin, Monocarboxylate transporter 1 | | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | 登録日 | 2020-10-14 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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6KJB
 | | wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167 | | 分子名称: | Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION | | 著者 | Wang, N, Lei, Z, Zheng, J, Jia, Z.C. | | 登録日 | 2019-07-22 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation.
Int J Mol Sci, 21, 2020
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6M6I
 | | Structure of HSV2 B-capsid portal vertex | | 分子名称: | Coiled coils chain 1, Coiled coils chain 2, Major capsid protein, ... | | 著者 | Wang, X.X, Wang, N. | | 登録日 | 2020-03-14 | | 公開日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Protein Cell, 11, 2020
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6M6H
 | | Structure of HSV2 C-capsid portal vertex | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | | 著者 | Wang, X.X, Wang, N. | | 登録日 | 2020-03-14 | | 公開日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Protein Cell, 11, 2020
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6M6G
 | | Structure of HSV2 viron capsid portal vertex | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Coiled coils, ... | | 著者 | Wang, X.X, Wang, N. | | 登録日 | 2020-03-14 | | 公開日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (5.39 Å) | | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Protein Cell, 11, 2020
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6C6Z
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7YDM
 | | Cryo-EM structure of CD97/Gq complex | | 分子名称: | Adhesion G protein-coupled receptor E5 subunit beta, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | He, Y, Wang, N. | | 登録日 | 2022-07-04 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structural basis of CD97 activation and G-protein coupling.
Cell Chem Biol, 30, 2023
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7YDP
 | | Cryo-EM structure of CD97/miniGs complex | | 分子名称: | Adhesion G protein-coupled receptor E5 subunit beta, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | He, Y, Wang, N. | | 登録日 | 2022-07-04 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of CD97 activation and G-protein coupling.
Cell Chem Biol, 30, 2023
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7YDH
 | | Cryo EM structure of CD97/miniG13 complex | | 分子名称: | Adhesion G protein-coupled receptor E5 subunit beta, G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | He, Y, Wang, N. | | 登録日 | 2022-07-04 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of CD97 activation and G-protein coupling.
Cell Chem Biol, 30, 2023
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7CWM
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7CWN
 | | P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Wang, N, Wang, X. | | 登録日 | 2020-08-29 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-01-13 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.
Cell Res., 31, 2021
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5VZR
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5VYH
 | | Crystal Structure of MERS-CoV S1 N-terminal Domain | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | | 著者 | Wang, N, Wrapp, D, Pallesen, J, Ward, A.B, McLellan, J.S. | | 登録日 | 2017-05-25 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7VKA
 | | Crystal Structure of GH3.6 in complex with an inhibitor | | 分子名称: | ADENOSINE MONOPHOSPHATE, GLYCEROL, Indole-3-acetic acid-amido synthetase GH3.6, ... | | 著者 | Wang, N, Luo, M, Bao, H, Huang, H. | | 登録日 | 2021-09-29 | | 公開日 | 2022-08-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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