7V0D
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3R1K
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![BU of 3r1k by Molmil](/molmil-images/mine/3r1k) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis H37Rv in complex with CoA and an acetamide moiety | 分子名称: | ACETAMIDE, COENZYME A, Enhanced intracellular survival protein | 著者 | Biswas, T, Chen, W, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2011-03-10 | 公開日 | 2011-06-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB. Proc.Natl.Acad.Sci.USA, 108, 2011
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3ITW
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3U9F
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3U9B
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4JD6
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![BU of 4jd6 by Molmil](/molmil-images/mine/4jd6) | Crystal structure of Mycobacterium tuberculosis Eis in complex with coenzyme A and tobramycin | 分子名称: | COENZYME A, Enhanced intracellular survival protein, TOBRAMYCIN | 著者 | Biswas, T, Chen, W, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2013-02-23 | 公開日 | 2013-10-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase eis. Chembiochem, 14, 2013
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6X6G
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![BU of 6x6g by Molmil](/molmil-images/mine/6x6g) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with droperidol | 分子名称: | 3-[1-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-2,3,4,5-tetrahydropyridin-4-yl]-1~{H}-benzimidazol-2-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-05-28 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance Rsc Med Chem, 12, 2021
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6X6I
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![BU of 6x6i by Molmil](/molmil-images/mine/6x6i) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT543 | 分子名称: | 4-(4-benzyl-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-05-28 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance Rsc Med Chem, 12, 2021
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6X6Y
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![BU of 6x6y by Molmil](/molmil-images/mine/6x6y) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1264 | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-05-29 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance Rsc Med Chem, 12, 2021
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6X7A
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![BU of 6x7a by Molmil](/molmil-images/mine/6x7a) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT572 | 分子名称: | 4-(4-cyclohexyl-3,4-dihydro-2~{H}-pyridin-1-yl)-1-(4-$l^{2}-fluoranylcyclohexa-1,3,5-trien-1-yl)butan-1-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-05-29 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance Rsc Med Chem, 12, 2021
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7JSA
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7JSL
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5EBV
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![BU of 5ebv by Molmil](/molmil-images/mine/5ebv) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 11c and CoA | 分子名称: | 5-(4-chlorophenyl)-~{N}-[3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)propyl]-4-methyl-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, CHLORIDE ION, COENZYME A, ... | 著者 | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2015-10-19 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis. Acs Chem.Biol., 11, 2016
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5EC4
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![BU of 5ec4 by Molmil](/molmil-images/mine/5ec4) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 13g and CoA | 分子名称: | 5-(3-chlorophenyl)-4-methyl-~{N}-(3-morpholin-4-ylpropyl)-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, COENZYME A, Enhanced intracellular survival protein | 著者 | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2015-10-20 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis. Acs Chem.Biol., 11, 2016
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5JW0
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![BU of 5jw0 by Molmil](/molmil-images/mine/5jw0) | Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT | 分子名称: | DNA (5'-D(P*AP*GP*GP*GP*TP*AP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ... | 著者 | Hou, C, Rohr, J, Tsodikov, O.V. | 登録日 | 2016-05-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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5JW2
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![BU of 5jw2 by Molmil](/molmil-images/mine/5jw2) | Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGATCCCT | 分子名称: | DNA (5'-D(*AP*GP*GP*GP*AP*TP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ... | 著者 | Hou, C, Rohr, J, Tsodikov, O.V. | 登録日 | 2016-05-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44, 2016
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5JVT
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5W33
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5WHF
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5W35
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5W36
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5DBJ
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![BU of 5dbj by Molmil](/molmil-images/mine/5dbj) | Crystal structure of halogenase PltA | 分子名称: | CHLORIDE ION, FADH2-dependent halogenase PltA, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Pang, A.H, Tsodikov, O.V. | 登録日 | 2015-08-21 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway. J.Struct.Biol., 192, 2015
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6B0U
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![BU of 6b0u by Molmil](/molmil-images/mine/6b0u) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a Lys-containing peptide | 分子名称: | COENZYME A, N-acetyltransferase Eis, Synthetic peptide ATKAPAKKA | 著者 | Biswas, T, Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2017-09-15 | 公開日 | 2018-01-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight. Biochemistry, 57, 2018
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6B3T
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![BU of 6b3t by Molmil](/molmil-images/mine/6b3t) | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b | 分子名称: | 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole, COENZYME A, N-acetyltransferase Eis, ... | 著者 | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Ngo, H.X, Tsodikov, O.V. | 登録日 | 2017-09-24 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis. ACS Infect Dis, 4, 2018
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6BZQ
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![BU of 6bzq by Molmil](/molmil-images/mine/6bzq) | Crystal structure of halogenase PltM in complex with FAD | 分子名称: | BROMIDE ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2017-12-25 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM. Nat Commun, 10, 2019
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