6X7A

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT572

This is a non-PDB format compatible entry.

Summary for 6X7A

• Entry DOI: 10.2210/pdb6x7a/pdb
• Descriptor: N-acetyltransferase Eis, 4-(4-cyclohexyl-3,4-dihydro-2~{H}-pyridin-1-yl)-1-(4-$l^{2}-fluoranylcyclohexa-1,3,5-trien-1-yl)butan-1-one, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: aminoglycoside, drug resistance, repurposing, acetylation, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 47299.46

Authors

Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2020-05-29, release date: 2021-06-02, Last modification date: 2023-10-18)

• Primary citation: Punetha, A.,Green, K.D.,Garzan, A.,Willby, M.J.,Pang, A.H.,Hou, C.,Holbrook, S.Y.L.,Krieger, K.,Posey, J.E.,Parish, T.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance; Rsc Med Chem, 12:1894-1909, 2021; DOI: 10.1039/D1MD00239B

Experimental method

X-RAY DIFFRACTION (2.08 Å)