6X7A

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT572

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005576	cellular_component	extracellular region
AAA	0005829	cellular_component	cytosol
AAA	0008080	molecular_function	N-acetyltransferase activity
AAA	0016746	molecular_function	acyltransferase activity
AAA	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
AAA	0030649	biological_process	aminoglycoside antibiotic catabolic process
AAA	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
AAA	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
AAA	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
AAA	0042802	molecular_function	identical protein binding
AAA	0043655	cellular_component	host extracellular space
AAA	0044161	cellular_component	host cell cytoplasmic vesicle
AAA	0046677	biological_process	response to antibiotic
AAA	0051701	biological_process	biological process involved in interaction with host
AAA	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
AAA	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
AAA	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
AAA	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
AAA	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:21628583

Chain	Residue	Details
AAA	TYR126

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583

Chain	Residue	Details
AAA	PHE402

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO

Chain	Residue	Details
AAA	VAL85
AAA	SER121

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO

Chain	Residue	Details
AAA	ARG93

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