6H9U
 
 | | Crystal structure of the BiP NBD and MANF SAP complex | | 分子名称: | D-MALATE, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor, ... | | 著者 | Yan, Y, Ron, D. | | 登録日 | 2018-08-06 | | 公開日 | 2019-02-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.
Nat Commun, 10, 2019
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6I7J
 | | Crystal structure of monomeric FICD mutant L258D | | 分子名称: | Adenosine monophosphate-protein transferase FICD, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... | | 著者 | Perera, L.A, Yan, Y, Read, R.J, Ron, D. | | 登録日 | 2018-11-16 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
Embo J., 38, 2019
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7A4U
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5O4P
 | | Crystal structure of AMPylated GRP78 | | 分子名称: | 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, SULFATE ION | | 著者 | Yan, Y, Chen, R, Ron, D, Read, R. | | 登録日 | 2017-05-30 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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7B7Z
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7B80
 | | DeAMPylation complex of monomeric FICD and AMPylated BiP (state 2) | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Perera, L.A, Ron, D. | | 登録日 | 2020-12-12 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Nat Commun, 12, 2021
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8S9D
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8S97
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8GLB
 | | Selenomethionine Derivatized Citrate Synthase (CitA) in Mycobacterium tuberculosis with Pyruvate | | 分子名称: | 1,2-ETHANEDIOL, PYRUVIC ACID, citrate synthase | | 著者 | Pathirage, R, Ronning, D, Favrot, L. | | 登録日 | 2023-03-21 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
Rsc Med Chem, 14, 2023
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8GMI
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8GMK
 | | Pyruvate bound structure of Citrate Synthase (CitA) in Mycobacterium Tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PYRUVIC ACID, ... | | 著者 | Pathirage, R, Ronning, D, Yamsek, M. | | 登録日 | 2023-03-26 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
Rsc Med Chem, 14, 2023
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8GI7
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8GM9
 | | Structure of Citrate Synthase(CitA) in Mycobacterium Tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, ACRYLIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pathirage, R, Ronning, D, Favrot, L. | | 登録日 | 2023-03-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
Rsc Med Chem, 14, 2023
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8GLL
 | | R149E variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | | 著者 | Pathirage, R, Ronning, D, Petit, C. | | 登録日 | 2023-03-22 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
Rsc Med Chem, 14, 2023
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8GIW
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8GMF
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3LJ0
 | | IRE1 complexed with ADP and Quercetin | | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Lee, K.P.K, Sicheri, F. | | 登録日 | 2010-01-25 | | 公開日 | 2010-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
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3IEG
 | | Crystal Structure of P58(IPK) TPR Domain at 2.5 A | | 分子名称: | DnaJ homolog subfamily C member 3 | | 著者 | Tao, J, Sha, B. | | 登録日 | 2009-07-22 | | 公開日 | 2010-03-31 | | 最終更新日 | 2019-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Crystal Structure of P58(IPK) TPR Fragment Reveals the Mechanism for its Molecular Chaperone Activity in UPR.
J.Mol.Biol., 64, 2010
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3LJ1
 | | IRE1 complexed with Cdk1/2 Inhibitor III | | 分子名称: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Serine/threonine-protein kinase/endoribonuclease IRE1 | | 著者 | Lee, K.P.K, Sicheri, F. | | 登録日 | 2010-01-25 | | 公開日 | 2010-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
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3LJ2
 | | IRE1 complexed with JAK Inhibitor I | | 分子名称: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Serine/threonine-protein kinase/endoribonuclease IRE1 | | 著者 | Lee, K.P.K, Sicheri, F. | | 登録日 | 2010-01-25 | | 公開日 | 2010-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
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3QD2
 | | Crystal structure of mouse PERK kinase domain | | 分子名称: | Eukaryotic translation initiation factor 2-alpha kinase 3 | | 著者 | Wenjun, C, Jingzhi, L, David, R, Bingdong, S. | | 登録日 | 2011-01-17 | | 公開日 | 2011-04-27 | | 最終更新日 | 2019-01-16 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | The structure of the PERK kinase domain suggests the mechanism for its activation.
Acta Crystallogr.,Sect.D, 67, 2011
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7D45
 | | eIF2B-eIF2(aP), aP1 complex | | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | | 著者 | Kashiwagi, K, Ito, T. | | 登録日 | 2020-09-22 | | 公開日 | 2020-12-09 | | 最終更新日 | 2021-01-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Mol.Cell, 81, 2021
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7D44
 | | eIF2B-eIF2(aP), aP2 complex | | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | | 著者 | Kashiwagi, K, Ito, T. | | 登録日 | 2020-09-22 | | 公開日 | 2020-12-09 | | 最終更新日 | 2021-01-27 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Mol.Cell, 81, 2021
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7D46
 | | eIF2B apo | | 分子名称: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | | 著者 | Kashiwagi, K, Ito, T. | | 登録日 | 2020-09-22 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Mol.Cell, 81, 2021
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7D43
 | | eIF2B-eIF2(aP), aPg complex | | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | | 著者 | Kashiwagi, K, Ito, T. | | 登録日 | 2020-09-22 | | 公開日 | 2020-12-09 | | 最終更新日 | 2021-01-27 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Mol.Cell, 81, 2021
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