7D44

eIF2B-eIF2(aP), aP2 complex

Summary for 7D44

Entry DOI	10.2210/pdb7d44/pdb
EMDB information	30569
Descriptor	Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ... (6 entities in total)
Functional Keywords	complex, translational control, translation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	594891.72
Authors	Kashiwagi, K.,Ito, T. (deposition date: 2020-09-22, release date: 2020-12-09, Last modification date: 2021-01-27)
Primary citation	Zyryanova, A.F.,Kashiwagi, K.,Rato, C.,Harding, H.P.,Crespillo-Casado, A.,Perera, L.A.,Sakamoto, A.,Nishimoto, M.,Yonemochi, M.,Shirouzu, M.,Ito, T.,Ron, D. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol.Cell, 81:88-, 2021 Cited by PubMed: 33220178 DOI: 10.1016/j.molcel.2020.10.031 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4 Å)

Structure validation