7D44

eIF2B-eIF2(aP), aP2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0005886	cellular_component	plasma membrane
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0009408	biological_process	response to heat
A	0009749	biological_process	response to glucose
A	0014003	biological_process	oligodendrocyte development
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0043434	biological_process	response to peptide hormone
A	0045948	biological_process	positive regulation of translational initiation
A	0050852	biological_process	T cell receptor signaling pathway
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0005886	cellular_component	plasma membrane
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0009408	biological_process	response to heat
B	0009749	biological_process	response to glucose
B	0014003	biological_process	oligodendrocyte development
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0043434	biological_process	response to peptide hormone
B	0045948	biological_process	positive regulation of translational initiation
B	0050852	biological_process	T cell receptor signaling pathway
C	0001541	biological_process	ovarian follicle development
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006446	biological_process	regulation of translational initiation
C	0007417	biological_process	central nervous system development
C	0009408	biological_process	response to heat
C	0009749	biological_process	response to glucose
C	0014003	biological_process	oligodendrocyte development
C	0042552	biological_process	myelination
C	0043434	biological_process	response to peptide hormone
C	0045948	biological_process	positive regulation of translational initiation
C	0048513	biological_process	animal organ development
C	0050852	biological_process	T cell receptor signaling pathway
D	0001541	biological_process	ovarian follicle development
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006446	biological_process	regulation of translational initiation
D	0007417	biological_process	central nervous system development
D	0009408	biological_process	response to heat
D	0009749	biological_process	response to glucose
D	0014003	biological_process	oligodendrocyte development
D	0042552	biological_process	myelination
D	0043434	biological_process	response to peptide hormone
D	0045948	biological_process	positive regulation of translational initiation
D	0048513	biological_process	animal organ development
D	0050852	biological_process	T cell receptor signaling pathway
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0007417	biological_process	central nervous system development
E	0008135	molecular_function	translation factor activity, RNA binding
E	0009058	biological_process	biosynthetic process
E	0009408	biological_process	response to heat
E	0009749	biological_process	response to glucose
E	0014003	biological_process	oligodendrocyte development
E	0043434	biological_process	response to peptide hormone
E	0045948	biological_process	positive regulation of translational initiation
E	0050852	biological_process	T cell receptor signaling pathway
F	0002183	biological_process	cytoplasmic translational initiation
F	0003743	molecular_function	translation initiation factor activity
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0007417	biological_process	central nervous system development
F	0008135	molecular_function	translation factor activity, RNA binding
F	0009058	biological_process	biosynthetic process
F	0009408	biological_process	response to heat
F	0009749	biological_process	response to glucose
F	0014003	biological_process	oligodendrocyte development
F	0043434	biological_process	response to peptide hormone
F	0045948	biological_process	positive regulation of translational initiation
F	0050852	biological_process	T cell receptor signaling pathway
G	0001541	biological_process	ovarian follicle development
G	0002183	biological_process	cytoplasmic translational initiation
G	0003743	molecular_function	translation initiation factor activity
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
G	0006417	biological_process	regulation of translation
G	0007417	biological_process	central nervous system development
G	0009408	biological_process	response to heat
G	0009749	biological_process	response to glucose
G	0014003	biological_process	oligodendrocyte development
G	0031369	molecular_function	translation initiation factor binding
G	0042552	biological_process	myelination
G	0043434	biological_process	response to peptide hormone
G	0045948	biological_process	positive regulation of translational initiation
G	0048513	biological_process	animal organ development
G	0050852	biological_process	T cell receptor signaling pathway
H	0001541	biological_process	ovarian follicle development
H	0002183	biological_process	cytoplasmic translational initiation
H	0003743	molecular_function	translation initiation factor activity
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
H	0006417	biological_process	regulation of translation
H	0007417	biological_process	central nervous system development
H	0009408	biological_process	response to heat
H	0009749	biological_process	response to glucose
H	0014003	biological_process	oligodendrocyte development
H	0031369	molecular_function	translation initiation factor binding
H	0042552	biological_process	myelination
H	0043434	biological_process	response to peptide hormone
H	0045948	biological_process	positive regulation of translational initiation
H	0048513	biological_process	animal organ development
H	0050852	biological_process	T cell receptor signaling pathway
I	0001541	biological_process	ovarian follicle development
I	0002183	biological_process	cytoplasmic translational initiation
I	0003743	molecular_function	translation initiation factor activity
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
I	0009408	biological_process	response to heat
I	0009749	biological_process	response to glucose
I	0014002	biological_process	astrocyte development
I	0014003	biological_process	oligodendrocyte development
I	0021766	biological_process	hippocampus development
I	0031369	molecular_function	translation initiation factor binding
I	0034976	biological_process	response to endoplasmic reticulum stress
I	0042552	biological_process	myelination
I	0043065	biological_process	positive regulation of apoptotic process
I	0043434	biological_process	response to peptide hormone
I	0045727	biological_process	positive regulation of translation
I	0045948	biological_process	positive regulation of translational initiation
I	0048708	biological_process	astrocyte differentiation
I	0050852	biological_process	T cell receptor signaling pathway
J	0001541	biological_process	ovarian follicle development
J	0002183	biological_process	cytoplasmic translational initiation
J	0003743	molecular_function	translation initiation factor activity
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
J	0006412	biological_process	translation
J	0006413	biological_process	translational initiation
J	0009408	biological_process	response to heat
J	0009749	biological_process	response to glucose
J	0014002	biological_process	astrocyte development
J	0014003	biological_process	oligodendrocyte development
J	0021766	biological_process	hippocampus development
J	0031369	molecular_function	translation initiation factor binding
J	0034976	biological_process	response to endoplasmic reticulum stress
J	0042552	biological_process	myelination
J	0043065	biological_process	positive regulation of apoptotic process
J	0043434	biological_process	response to peptide hormone
J	0045727	biological_process	positive regulation of translation
J	0045948	biological_process	positive regulation of translational initiation
J	0048708	biological_process	astrocyte differentiation
J	0050852	biological_process	T cell receptor signaling pathway
K	0000423	biological_process	mitophagy
K	0003676	molecular_function	nucleic acid binding
K	0003723	molecular_function	RNA binding
K	0003743	molecular_function	translation initiation factor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
K	0006412	biological_process	translation
K	0006413	biological_process	translational initiation
K	0006417	biological_process	regulation of translation
K	0006446	biological_process	regulation of translational initiation
K	0010494	cellular_component	cytoplasmic stress granule
K	0016020	cellular_component	membrane
K	0032057	biological_process	negative regulation of translational initiation in response to stress
K	0033290	cellular_component	eukaryotic 48S preinitiation complex
K	0034063	biological_process	stress granule assembly
K	0034198	biological_process	cellular response to amino acid starvation
K	0034599	biological_process	cellular response to oxidative stress
K	0034605	biological_process	cellular response to heat
K	0034644	biological_process	cellular response to UV
K	0034976	biological_process	response to endoplasmic reticulum stress
K	0036490	biological_process	regulation of translation in response to endoplasmic reticulum stress
K	0036499	biological_process	PERK-mediated unfolded protein response
K	0043022	molecular_function	ribosome binding
K	0044207	cellular_component	translation initiation ternary complex
K	0045202	cellular_component	synapse
K	0070062	cellular_component	extracellular exosome
K	0097451	cellular_component	glial limiting end-foot
K	0140468	biological_process	HRI-mediated signaling
K	0160296	molecular_function	cap-dependent translation initiation factor activity
K	0160297	molecular_function	IRES-mediated translation initiation factor activity
K	1904373	biological_process	response to kainic acid
K	1990737	biological_process	response to manganese-induced endoplasmic reticulum stress
K	2000676	biological_process	positive regulation of type B pancreatic cell apoptotic process
L	0000423	biological_process	mitophagy
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0003743	molecular_function	translation initiation factor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
L	0006412	biological_process	translation
L	0006413	biological_process	translational initiation
L	0006417	biological_process	regulation of translation
L	0006446	biological_process	regulation of translational initiation
L	0010494	cellular_component	cytoplasmic stress granule
L	0016020	cellular_component	membrane
L	0032057	biological_process	negative regulation of translational initiation in response to stress
L	0033290	cellular_component	eukaryotic 48S preinitiation complex
L	0034063	biological_process	stress granule assembly
L	0034198	biological_process	cellular response to amino acid starvation
L	0034599	biological_process	cellular response to oxidative stress
L	0034605	biological_process	cellular response to heat
L	0034644	biological_process	cellular response to UV
L	0034976	biological_process	response to endoplasmic reticulum stress
L	0036490	biological_process	regulation of translation in response to endoplasmic reticulum stress
L	0036499	biological_process	PERK-mediated unfolded protein response
L	0043022	molecular_function	ribosome binding
L	0044207	cellular_component	translation initiation ternary complex
L	0045202	cellular_component	synapse
L	0070062	cellular_component	extracellular exosome
L	0097451	cellular_component	glial limiting end-foot
L	0140468	biological_process	HRI-mediated signaling
L	0160296	molecular_function	cap-dependent translation initiation factor activity
L	0160297	molecular_function	IRES-mediated translation initiation factor activity
L	1904373	biological_process	response to kainic acid
L	1990737	biological_process	response to manganese-induced endoplasmic reticulum stress
L	2000676	biological_process	positive regulation of type B pancreatic cell apoptotic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Region: {"description":"May bind the chemical integrated stress response (ISR) inhibitor ISRIB","evidences":[{"source":"PubMed","id":"25858979","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by HRI","evidences":[{"source":"UniProtKB","id":"P83268","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38340717","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---