8GI7

C143A variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis

Summary for 8GI7

Entry DOI	10.2210/pdb8gi7/pdb
Descriptor	citrate synthase (unknown stereospecificity), CITRATE ANION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	citrate synthesis, tca cycle, c143a variant, cytosolic protein
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	4
Total formula weight	165016.90
Authors	Pathirage, R.,Ronning, D. (deposition date: 2023-03-13, release date: 2023-06-07, Last modification date: 2023-11-08)
Primary citation	Pathirage, R.,Favrot, L.,Petit, C.,Yamsek, M.,Singh, S.,Mallareddy, J.R.,Rana, S.,Natarajan, A.,Ronning, D.R. Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14:921-933, 2023 Cited by PubMed: 37252106 DOI: 10.1039/d3md00058c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation