7D45
eIF2B-eIF2(aP), aP1 complex
Summary for 7D45
| Entry DOI | 10.2210/pdb7d45/pdb |
| EMDB information | 30570 |
| Descriptor | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ... (6 entities in total) |
| Functional Keywords | complex, translational control, translation |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 11 |
| Total formula weight | 558650.56 |
| Authors | Kashiwagi, K.,Ito, T. (deposition date: 2020-09-22, release date: 2020-12-09, Last modification date: 2021-01-27) |
| Primary citation | Zyryanova, A.F.,Kashiwagi, K.,Rato, C.,Harding, H.P.,Crespillo-Casado, A.,Perera, L.A.,Sakamoto, A.,Nishimoto, M.,Yonemochi, M.,Shirouzu, M.,Ito, T.,Ron, D. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol.Cell, 81:88-, 2021 Cited by PubMed: 33220178DOI: 10.1016/j.molcel.2020.10.031 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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