2F88
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8GD7
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![BU of 8gd7 by Molmil](/molmil-images/mine/8gd7) | Loop Deleted DNA Polymerase Theta Polymerase Domain in Complex with Double Strand DNA Overhang and Inhibitor | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-(3-methyl-2-oxoimidazolidin-1-yl)-4,6-bis(trifluoromethyl)phenyl (4-fluorophenyl)methylcarbamate, DNA Primer, ... | 著者 | Fried, W.A, Chen, X.S, Li, S.X. | 登録日 | 2023-03-03 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Discovery of a small-molecule inhibitor that traps Pol theta on DNA and synergizes with PARP inhibitors. Nat Commun, 15, 2024
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7PB9
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![BU of 7pb9 by Molmil](/molmil-images/mine/7pb9) | Crystal structure of tandem WH domains of Vps25 from Odinarchaeota | 分子名称: | Tandem WH domains of Vps25 | 著者 | Salzer, R, Bellini, D, Papatziamou, D, Robinson, N.P, Lowe, J. | 登録日 | 2021-08-01 | 公開日 | 2022-06-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery. Nat Commun, 13, 2022
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8BXT
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1HSX
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3LZT
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![BU of 3lzt by Molmil](/molmil-images/mine/3lzt) | REFINEMENT OF TRICLINIC LYSOZYME AT ATOMIC RESOLUTION | 分子名称: | ACETATE ION, LYSOZYME, NITRATE ION | 著者 | Walsh, M.A, Schneider, T, Sieker, L.C, Dauter, Z, Lamzin, V, Wilson, K.S. | 登録日 | 1997-03-23 | 公開日 | 1998-03-25 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (0.925 Å) | 主引用文献 | Refinement of triclinic hen egg-white lysozyme at atomic resolution. Acta Crystallogr.,Sect.D, 54, 1998
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5V1L
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![BU of 5v1l by Molmil](/molmil-images/mine/5v1l) | Structure of S-GNA dodecamer | 分子名称: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), SPERMINE, STRONTIUM ION | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2017-03-02 | 公開日 | 2017-06-14 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. J. Am. Chem. Soc., 139, 2017
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5V1K
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![BU of 5v1k by Molmil](/molmil-images/mine/5v1k) | Structure of R-GNA dodecamer | 分子名称: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3') | 著者 | Pallan, P.S, Egli, M. | 登録日 | 2017-03-02 | 公開日 | 2017-06-21 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. J. Am. Chem. Soc., 2017
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5V2H
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![BU of 5v2h by Molmil](/molmil-images/mine/5v2h) | RNA octamer containing glycol nucleic acid, SgnT | 分子名称: | COBALT HEXAMMINE(III), MAGNESIUM ION, RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3') | 著者 | Harp, J.M, Egli, M. | 登録日 | 2017-03-04 | 公開日 | 2017-06-14 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.080013 Å) | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. J. Am. Chem. Soc., 139, 2017
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5DER
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![BU of 5der by Molmil](/molmil-images/mine/5der) | RNA oligonucleotide containing (R)-C5'-ME-2'F U | 分子名称: | RNA oligonucleotide containing (R)-C5'-Me-2'-FU | 著者 | Harp, J.M, Egli, M. | 登録日 | 2015-08-25 | 公開日 | 2016-06-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. J.Org.Chem., 81, 2016
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5DEK
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![BU of 5dek by Molmil](/molmil-images/mine/5dek) | RNA octamer containing dT | 分子名称: | COBALT HEXAMMINE(III), RNA oligonucleotide containing dT | 著者 | Harp, J.M, Egli, M. | 登録日 | 2015-08-25 | 公開日 | 2016-07-20 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.993 Å) | 主引用文献 | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. J.Org.Chem., 81, 2016
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5D8T
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![BU of 5d8t by Molmil](/molmil-images/mine/5d8t) | RNA octamer containing (S)-5' methyl, 2'-F U. | 分子名称: | COBALT HEXAMMINE(III), RNA oligonucleotide containing (S)-C5'-Me-2'-FU | 著者 | Harp, J.M, Egli, M. | 登録日 | 2015-08-17 | 公開日 | 2016-06-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. J.Org.Chem., 81, 2016
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6AXR
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6AXW
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1HSW
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6V9U
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![BU of 6v9u by Molmil](/molmil-images/mine/6v9u) | Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14c | 分子名称: | 2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Critton, D.A. | 登録日 | 2019-12-16 | 公開日 | 2020-08-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). Acs Med.Chem.Lett., 11, 2020
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7RC9
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2UYM
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2UYI
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![BU of 2uyi by Molmil](/molmil-images/mine/2uyi) | Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33 | 分子名称: | (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | 著者 | Lee, T.T. | 登録日 | 2007-04-07 | 公開日 | 2007-05-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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3IX0
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2PG2
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4LZT
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![BU of 4lzt by Molmil](/molmil-images/mine/4lzt) | ATOMIC RESOLUTION REFINEMENT OF TRICLINIC HEW LYSOZYME AT 295K | 分子名称: | LYSOZYME, NITRATE ION | 著者 | Walsh, M.A, Schneider, T, Sieker, L.C, Dauter, Z, Lamzin, V, Wilson, K.S. | 登録日 | 1997-03-31 | 公開日 | 1998-04-01 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Refinement of triclinic hen egg-white lysozyme at atomic resolution. Acta Crystallogr.,Sect.D, 54, 1998
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2LPT
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