8GD7

Loop Deleted DNA Polymerase Theta Polymerase Domain in Complex with Double Strand DNA Overhang and Inhibitor

Summary for 8GD7

• Entry DOI: 10.2210/pdb8gd7/pdb
• Descriptor: DNA polymerase theta, DNA Template, DNA Primer, ... (6 entities in total)
• Functional Keywords: dna polymerase theta, inhibitor, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 85224.14

Authors

Fried, W.A.,Chen, X.S.,Li, S.X. (deposition date: 2023-03-03, release date: 2024-06-19)

• Primary citation: Fried, W.,Tyagi, M.,Minakhin, L.,Chandramouly, G.,Tredinnick, T.,Ramanjulu, M.,Auerbacher, W.,Calbert, M.,Rusanov, T.,Hoang, T.,Borisonnik, N.,Betsch, R.,Krais, J.J.,Wang, Y.,Vekariya, U.M.,Gordon, J.,Morton, G.,Kent, T.,Skorski, T.,Johnson, N.,Childers, W.,Chen, X.S.,Pomerantz, R.T.; Discovery of a small-molecule inhibitor that traps Pol theta on DNA and synergizes with PARP inhibitors.; Nat Commun, 15:2862-2862, 2024; PubMed: 38580648; DOI: 10.1038/s41467-024-46593-1

Experimental method

X-RAY DIFFRACTION (3.24 Å)