6V9U

Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14c

Summary for 6V9U

• Entry DOI: 10.2210/pdb6v9u/pdb
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: toll-like receptor, pattern recognition receptor, pathogen-associated molecular patterns, innate immunity, endosomal receptor, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 194842.52

Authors

Critton, D.A. (deposition date: 2019-12-16, release date: 2020-08-12, Last modification date: 2023-10-11)

• Primary citation: Mussari, C.P.,Dodd, D.S.,Sreekantha, R.K.,Pasunoori, L.,Wan, H.,Posy, S.L.,Critton, D.,Ruepp, S.,Subramanian, M.,Watson, A.,Davies, P.,Schieven, G.L.,Salter-Cid, L.M.,Srivastava, R.,Tagore, D.M.,Dudhgaonkar, S.,Poss, M.A.,Carter, P.H.,Dyckman, A.J.; Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9).; Acs Med.Chem.Lett., 11:1751-1758, 2020; PubMed: 32944143; DOI: 10.1021/acsmedchemlett.0c00264

Experimental method

X-RAY DIFFRACTION (2.65 Å)