6WTO
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![BU of 6wto by Molmil](/molmil-images/mine/6wto) | Human JAK2 JH1 domain in complex with Baricitinib | 分子名称: | 1,2-ETHANEDIOL, Baricitinib, Tyrosine-protein kinase JAK2 | 著者 | Yu, S, Nithianantham, S, Fischer, M. | 登録日 | 2020-05-03 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138, 2021
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8XJM
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![BU of 8xjm by Molmil](/molmil-images/mine/8xjm) | Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex | 分子名称: | Antibody fragment scFv16, Engineered miniGq, Fusion tag,Prostaglandin F2-alpha receptor,LgBiT, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJK
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![BU of 8xjk by Molmil](/molmil-images/mine/8xjk) | Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJO
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![BU of 8xjo by Molmil](/molmil-images/mine/8xjo) | U46619 bound Thromboxane A2 receptor-Gq Protein Complex | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJN
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![BU of 8xjn by Molmil](/molmil-images/mine/8xjn) | Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8XJL
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![BU of 8xjl by Molmil](/molmil-images/mine/8xjl) | PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex | 分子名称: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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7VUZ
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![BU of 7vuz by Molmil](/molmil-images/mine/7vuz) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV4
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![BU of 7vv4 by Molmil](/molmil-images/mine/7vv4) | |
7VDM
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![BU of 7vdm by Molmil](/molmil-images/mine/7vdm) | |
7VV5
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![BU of 7vv5 by Molmil](/molmil-images/mine/7vv5) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VDL
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![BU of 7vdl by Molmil](/molmil-images/mine/7vdl) | |
7VDH
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![BU of 7vdh by Molmil](/molmil-images/mine/7vdh) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-09-07 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV0
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![BU of 7vv0 by Molmil](/molmil-images/mine/7vv0) | |
7VV6
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![BU of 7vv6 by Molmil](/molmil-images/mine/7vv6) | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local) | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Mas-related G-protein coupled receptor member X2 | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VUY
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7VV3
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8KG5
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![BU of 8kg5 by Molmil](/molmil-images/mine/8kg5) | Prefusion RSV F Bound to Lonafarnib and D25 Fab | 分子名称: | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ... | 著者 | Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X. | 登録日 | 2023-08-17 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein. Signal Transduct Target Ther, 9, 2024
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