5ENO
 
 | | MBX2319 bound structure of bacterial efflux pump. | | 分子名称: | 3,3-dimethyl-8-morpholin-4-yl-6-(2-phenylethylsulfanyl)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5ENS
 | | Rhodamine bound structure of bacterial efflux pump. | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, RHODAMINE 6G | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5EN5
 | | Apo structure of bacterial efflux pump. | | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | | 登録日 | 2015-11-09 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
6ZO8
 | | Minocycline binding to the deep binding pocket of AcrB-G621P | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOD
 | | Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8 groove, and TM1/TM2 groove of the fully induced AcrB T protomer | | 分子名称: | 1,2-ETHANEDIOL, DARPIN, DECANE, ... | | 著者 | Oswald, C, Tam, H.K, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZO5
 | | Fusidic acid binding to the TM1/TM2 groove of AcrB-G619P_G621P | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZO9
 | | Binding of two rifabutins to the access pocket of AcrB-G621P T protomer | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOB
 | | 3-Formylrifamycin SV binding to the access pocket of AcrB L protomer | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZO6
 | | Minocycline binding to the deep binding pocket of AcrB-G619P | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOF
 | | Fusidic acid binding to the TM7/TM8 groove of AcrB-F380A T protomer | | 分子名称: | DARPIN, DECANE, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZO7
 | | 3-Formylrifamycin SV binding to the access pocket of AcrB-G619P L and T protomer | | 分子名称: | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOG
 | | Minocycline binding to the deep binding pocket of AcrB-I38F_I671T | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, 1,2-ETHANEDIOL, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOH
 | | 3-Formylrifamycin SV binding to the access pocket of AcrB-G619P_G621P L and T protomers | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOE
 | | AcrB-F563A symmetric T protomer | | 分子名称: | 1,2-ETHANEDIOL, DARPIN, DECANE, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOA
 | | Partially induced AcrB T protomer and DDM binding to the TM8/PC2 pathway of AcrB L2 protomer | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DARPIN, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6ZOC
 | | Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer | | 分子名称: | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, DARPIN, ... | | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | | 登録日 | 2020-07-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
|
|
6EUQ
 | | MdfA(Q131R/L339E) | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACETATE ION, HEXANE, ... | | 著者 | Tam, H.K, Zomot, E, Bibi, E, Pos, K.M. | | 登録日 | 2017-10-31 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter.
J. Mol. Biol., 430, 2018
|
|
6Q4P
 | | Fusidic acid bound AcrB_N298A | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CHLORIDE ION, ... | | 著者 | Tam, H.K, Pos, K.M. | | 登録日 | 2018-12-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
|
|
5MKK
 | | Crystal structure of the heterodimeric ABC transporter TmrAB, a homolog of the antigen translocation complex TAP | | 分子名称: | Multidrug resistance ABC transporter ATP-binding and permease protein, SULFATE ION | | 著者 | Noell, A, Thomas, C, Tomasiak, T.M, Olieric, V, Wang, M, Diederichs, K, Stroud, R.M, Pos, K.M, Tampe, R. | | 登録日 | 2016-12-05 | | 公開日 | 2017-01-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
6Q4O
 | | Fusidic acid bound AcrB_I27A | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPIN, DECANE, ... | | 著者 | Tam, H.K, Pos, K.M. | | 登録日 | 2018-12-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
|
|
6Q4N
 | | Fusidic acid bound AcrB_V340A | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPin, DECANE, ... | | 著者 | Tam, H.K, Pos, K.M. | | 登録日 | 2018-12-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB.
J.Mol.Biol., 432, 2020
|
|
6RX9
 | |
6RXB
 | | Crystal structure of TetR-Q116A from Acinetobacter baumannii AYE in complex with minocycline | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Tam, H.K, Himpich, S, Pos, K.M. | | 登録日 | 2019-06-07 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants
Front Microbiol, 2021
|
|
5JMN
 | | Fusidic acid bound AcrB | | 分子名称: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, DARPin, ... | | 著者 | Oswald, C, Tam, H.K, Pos, K.M. | | 登録日 | 2016-04-29 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.
Nat Commun, 7, 2016
|
|
4DX7
 | | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | | 分子名称: | Acriflavine resistance protein B, DARPIN, DECANE, ... | | 著者 | Eicher, T, Cha, H, Seeger, M.A, Brandstaetter, L, El-Delik, J, Bohnert, J.A, Kern, W.V, Verrey, F, Gruetter, M.G, Diederichs, K, Pos, K.M. | | 登録日 | 2012-02-27 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.253 Å) | | 主引用文献 | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
