7ZR0
 
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7ZR5
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7ZR6
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8AG4
 | | Vaccinia C16 protein bound to Ku70/Ku80 | | 分子名称: | Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | | 登録日 | 2022-07-19 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
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8AG3
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8AG5
 | | Vaccinia C16 protein bound to Ku70/Ku80 | | 分子名称: | Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 | | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | | 登録日 | 2022-07-19 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
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5ECG
 | | Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) | | 分子名称: | Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ... | | 著者 | Day, M, Oliver, A.W, Pearl, L.H. | | 登録日 | 2015-10-20 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX.
Cell Rep, 13, 2015
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4BB7
 | | Crystal structure of the yeast Rsc2 BAH domain | | 分子名称: | CHLORIDE ION, CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC2, GLYCEROL, ... | | 著者 | Chambers, A.L, Pearl, L.H, Oliver, A.W, Downs, J.A. | | 登録日 | 2012-09-20 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Bah Domain of Rsc2 is a Histone H3 Binding Domain.
Nucleic Acids Res., 41, 2013
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4BA9
 | | The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1 | | 分子名称: | DNA POLYMERASE KAPPA, DNA REPAIR PROTEIN REV1, MAGNESIUM ION, ... | | 著者 | Grummitt, C.G, Kilkenny, M.L, Frey, A, Roe, S.M, Oliver, A.W, Sale, J.E, Pearl, L.H. | | 登録日 | 2012-09-12 | | 公開日 | 2013-09-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | The Structural Basis for the Coordination of Y- Family Translesion DNA Polymerases by Rev1
To be Published
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4AV1
 | | Crystal structure of the human PARP-1 DNA binding domain in complex with DNA | | 分子名称: | 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3', 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3', POLY [ADP-RIBOSE] POLYMERASE 1, ... | | 著者 | Ali, A.A.E, Timinszky, G, Arribas-Bosacoma, R, Kozlowski, M, Hassa, P.O, Hassler, M, Ladurner, A.G, Pearl, L.H, Oliver, A.W. | | 登録日 | 2012-05-23 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks
Nat.Struct.Mol.Biol., 19, 2012
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2CE9
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2CE8
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2NC9
 | | Apo solution structure of Hop TPR2A | | 分子名称: | Stress-induced-phosphoprotein 1 | | 著者 | Darby, J.F, Vidler, L.R, Simpson, P.J, Matthews, S.J, Sharp, S.Y, Pearl, L.H, Hoelder, S, Workman, P. | | 登録日 | 2016-03-23 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
Sci Rep, 10, 2020
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3P23
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2QDJ
 | | Crystal structure of the Retinoblastoma protein N-domain provides insight into tumor suppression, ligand interaction and holoprotein architecture | | 分子名称: | Retinoblastoma-associated protein | | 著者 | Hassler, M, Mittnacht, S, Pearl, L.H. | | 登録日 | 2007-06-21 | | 公開日 | 2008-01-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.
Mol.Cell, 28, 2007
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5MG8
 | | Crystal structure of the S.pombe Smc5/6 hinge domain | | 分子名称: | GLYCEROL, SULFATE ION, Structural maintenance of chromosomes protein 5, ... | | 著者 | Alt, A, Pearl, L.H, Oliver, A.W. | | 登録日 | 2016-11-21 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Nat Commun, 8, 2017
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6HM5
 | | Crystal structure of TOPBP1 BRCT0,1,2 in complex with a RAD9 phosphopeptide | | 分子名称: | Cell cycle checkpoint control protein RAD9A, DNA topoisomerase II binding protein 1 | | 著者 | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | | 登録日 | 2018-09-12 | | 公開日 | 2018-10-17 | | 実験手法 | X-RAY DIFFRACTION (2.330038 Å) | | 主引用文献 | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Elife, 7, 2018
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6HM3
 | | Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide | | 分子名称: | CALCIUM ION, DNA replication regulator sld3, GLYCEROL, ... | | 著者 | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | | 登録日 | 2018-09-12 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.77263618 Å) | | 主引用文献 | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Elife, 7, 2018
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6HM4
 | | Crystal structure of Rad4 BRCT1,2 in complex with a Mdb1 phosphopeptide | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DNA damage response protein Mdb1, ... | | 著者 | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | | 登録日 | 2018-09-12 | | 公開日 | 2018-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.770186 Å) | | 主引用文献 | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Elife, 7, 2018
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2BYE
 | | NMR solution structure of phospholipase c epsilon RA 1 domain | | 分子名称: | PHOSPHOLIPASE C, EPSILON 1 | | 著者 | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | | 登録日 | 2005-08-01 | | 公開日 | 2006-02-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon.
Mol.Cell, 21, 2006
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2BYF
 | | NMR solution structure of phospholipase c epsilon RA 2 domain | | 分子名称: | PHOSPHOLIPASE C, EPSILON 1 | | 著者 | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | | 登録日 | 2005-08-01 | | 公開日 | 2006-02-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon.
Mol.Cell, 21, 2006
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2BRF
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2BRC
 | | Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90. | | 分子名称: | 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | | 著者 | Roe, S.M, Pearl, L.H, Prodromou, C. | | 登録日 | 2005-05-04 | | 公開日 | 2005-09-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Bioorg. Med. Chem. Lett., 15, 2005
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2BRE
 | | STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. | | 分子名称: | 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | | 著者 | Roe, S.M, Pearl, L.H, Prodromou, C. | | 登録日 | 2005-05-04 | | 公開日 | 2005-09-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Bioorg. Med. Chem. Lett., 15, 2005
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2C2V
 | | Crystal structure of the CHIP-UBC13-UEV1a complex | | 分子名称: | STIP1 homology and U box-containing protein 1, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1 | | 著者 | Zhang, M, Roe, S.M, Pearl, L.H. | | 登録日 | 2005-09-30 | | 公開日 | 2005-11-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Mol. Cell, 20, 2005
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