3P23
Crystal structure of the Human kinase and RNase domains in complex with ADP
Summary for 3P23
Entry DOI | 10.2210/pdb3p23/pdb |
Descriptor | Serine/threonine-protein kinase/endoribonuclease IRE1, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | kinase domain, kinase and rnase function, atp binding ssrna binding, dephosphorylated, hydrolase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type I membrane protein: O75460 |
Total number of polymer chains | 4 |
Total formula weight | 199696.02 |
Authors | Ali, M.M.U.,Pearl, L.H. (deposition date: 2010-10-01, release date: 2011-02-23, Last modification date: 2024-02-21) |
Primary citation | Ali, M.M.,Bagratuni, T.,Davenport, E.L.,Nowak, P.R.,Silva-Santisteban, M.C.,Hardcastle, A.,McAndrews, C.,Rowlands, M.G.,Morgan, G.J.,Aherne, W.,Collins, I.,Davies, F.E.,Pearl, L.H. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. Embo J., 30:894-905, 2011 Cited by PubMed: 21317875DOI: 10.1038/emboj.2011.18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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