3P23

Crystal structure of the Human kinase and RNase domains in complex with ADP

Summary for 3P23

Entry DOI	10.2210/pdb3p23/pdb
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	kinase domain, kinase and rnase function, atp binding ssrna binding, dephosphorylated, hydrolase, transferase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein: O75460
Total number of polymer chains	4
Total formula weight	199696.02
Authors	Ali, M.M.U.,Pearl, L.H. (deposition date: 2010-10-01, release date: 2011-02-23, Last modification date: 2024-02-21)
Primary citation	Ali, M.M.,Bagratuni, T.,Davenport, E.L.,Nowak, P.R.,Silva-Santisteban, M.C.,Hardcastle, A.,McAndrews, C.,Rowlands, M.G.,Morgan, G.J.,Aherne, W.,Collins, I.,Davies, F.E.,Pearl, L.H. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. Embo J., 30:894-905, 2011 Cited by PubMed: 21317875 DOI: 10.1038/emboj.2011.18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation