3P23
Crystal structure of the Human kinase and RNase domains in complex with ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine/threonine-protein kinase/endoribonuclease IRE1 | polymer | 432 | 49448.5 | 4 | UniProt (O75460) Pfam (PF00069) Pfam (PF06479) | Homo sapiens (human) | Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a, Endoplasmic reticulum-to-nucleus signaling 1, Serine/threonine-protein kinase, Endoribonuclease |
| 2 | E, H, J, L (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | F, I, K, M (A, B, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 4 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 397 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 547 - 977 (UniProt: O75460)
| PDB | External Database | Details |
|---|---|---|
| Met 546 | - | expression tag |
| Thr 924 | Ser 924 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 197793.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1902.1 | |
| All* | Total formula weight | 199696.0 |
