3OJ2
| |
3OJM
| |
3OJV
| Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop | 分子名称: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Basic fibroblast growth factor receptor 1, Heparin-binding growth factor 1 | 著者 | Beenken, A, Mohammadi, M. | 登録日 | 2010-08-23 | 公開日 | 2011-12-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
|
|
1RY7
| Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1 | 分子名称: | Fibroblast growth factor receptor 3, Heparin-binding growth factor 1 | 著者 | Olsen, S.K, Ibrahimi, O.A, Raucci, A, Zhang, F, Eliseenkova, A.V, Yayon, A, Basilico, C, Linhardt, R.J, Schlessinger, J, Mohammadi, M. | 登録日 | 2003-12-19 | 公開日 | 2004-02-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
1CVS
| CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX | 分子名称: | FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION | 著者 | Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M. | 登録日 | 1999-08-24 | 公開日 | 2000-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for FGF receptor dimerization and activation. Cell(Cambridge,Mass.), 98, 1999
|
|
1EVT
| CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1) | 分子名称: | PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION | 著者 | Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M. | 登録日 | 2000-04-20 | 公開日 | 2000-05-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101, 2000
|
|
1EV2
| CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2) | 分子名称: | PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION | 著者 | Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M. | 登録日 | 2000-04-19 | 公開日 | 2000-05-31 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101, 2000
|
|
4QQ5
| Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations | 分子名称: | Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide | 著者 | Huang, Z, Mohammadi, M. | 登録日 | 2014-06-26 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10, 2015
|
|
4QQJ
| |
4QQT
| |
4QRC
| |
4J99
| |
4J96
| |
4J97
| |
4J98
| |
4J95
| |
4K33
| Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma | 分子名称: | Fibroblast growth factor receptor 3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Huang, Z, Chen, H, Mohammadi, M. | 登録日 | 2013-04-10 | 公開日 | 2013-09-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3405 Å) | 主引用文献 | Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation. Structure, 21, 2013
|
|
1IJT
| Crystal Structure of Fibroblast Growth Factor 4 (FGF4) | 分子名称: | SULFATE ION, fibroblast growth factor 4 | 著者 | Bellosta, P, Plotnikov, A.N, Eliseenkova, A.V, Basilico, C, Mohammadi, M. | 登録日 | 2001-04-29 | 公開日 | 2001-08-15 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. Mol.Cell.Biol., 21, 2001
|
|
1FQ9
| CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX | 分子名称: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 2, ... | 著者 | Schlessinger, J, Plotnikov, A.N, Ibrahimi, O.A, Eliseenkova, A.V, Yeh, B.K, Yayon, A, Linhardt, R.J, Mohammadi, M. | 登録日 | 2000-09-04 | 公開日 | 2000-09-27 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol.Cell, 6, 2000
|
|
1IIL
| CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2 | 分子名称: | FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2 | 著者 | Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M. | 登録日 | 2001-04-23 | 公開日 | 2001-05-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
1IHK
| CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9) | 分子名称: | GLIA-ACTIVATING FACTOR, PHOSPHATE ION | 著者 | Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M. | 登録日 | 2001-04-19 | 公開日 | 2001-05-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. J.Biol.Chem., 276, 2001
|
|
1II4
| CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2 | 分子名称: | FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2 | 著者 | Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M. | 登録日 | 2001-04-20 | 公開日 | 2001-05-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
2PSQ
| |
2PVY
| |
2PZR
| |