Search by PDB author

Crystal structure of human thymidylate synthase mutant Y202C
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者	Pozzi, C, Mangani, S.
登録日	2013-12-16
公開日	2015-01-21
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.26 Å)
主引用文献	Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife, 11, 2022

4O5B

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
分子名称:	(2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid, Integrase, SULFATE ION
著者	Feng, L, Kvaratskhelia, M.
登録日	2013-12-19
公開日	2014-07-02
最終更新日	2017-11-22
実験手法	X-RAY DIFFRACTION (2.37 Å)
主引用文献	A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase. Plos Pathog., 10, 2014

4O55

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
分子名称:	(2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid, Integrase, SULFATE ION
著者	Feng, L, Kvaratskhelia, M.
登録日	2013-12-19
公開日	2014-07-02
最終更新日	2017-11-22
実験手法	X-RAY DIFFRACTION (2.24 Å)
主引用文献	A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase. Plos Pathog., 10, 2014

8DSR

Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 in complex with UCB7362
分子名称:	(2E,6S)-6-{2-chloro-3-[(2-cyclopropylpyrimidin-5-yl)amino]phenyl}-2-imino-6-methyl-3-[(2S,4S)-2-methyloxan-4-yl]-1,3-diazinan-4-one, Plasmepsin X
著者	Abendroth, J, Lorimer, D.D.
登録日	2022-07-22
公開日	2022-10-19
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.85 Å)
主引用文献	Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 . J.Med.Chem., 65, 2022

1NF1

THE GAP RELATED DOMAIN OF NEUROFIBROMIN
分子名称:	PROTEIN (NEUROFIBROMIN)
著者	Scheffzek, K, Ahmadian, M.R, Wiesmueller, L, Kabsch, W, Stege, P, Schmitz, F, Wittinghofer, A.
登録日	1998-07-08
公開日	1999-07-20
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structural analysis of the GAP-related domain from neurofibromin and its implications. EMBO J., 17, 1998

7POM

Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
分子名称:	Carbonic anhydrase 9, ZINC ION, methyl 2-chloranyl-4-cyclohexylsulfanyl-5-sulfamoyl-benzoate
著者	Leitans, J, Tars, K.
登録日	2021-09-09
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7Q0D

Human carbonic anhydrase I in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate
分子名称:	1,2-ETHANEDIOL, ACETATE ION, Carbonic anhydrase 1, ...
著者	Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S.
登録日	2021-10-14
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.24 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7PUU

Crystal structure of carbonic anhydrase XII with methyl 4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzoate
分子名称:	1,2-ETHANEDIOL, Carbonic anhydrase 12, ZINC ION, ...
著者	Smirnov, A, Manakova, E, Grazulis, S.
登録日	2021-09-30
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.51 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7Q0E

Human Carbonic Anhydrase II in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate
分子名称:	BICINE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
著者	Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S.
登録日	2021-10-14
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.3 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7PUW

Crystal structure of carbonic anhydrase XII with methyl 2-chloro-4-[(2-phenylethyl)sulfanyl]-5-sulfamoylbenzoate
分子名称:	1,2-ETHANEDIOL, Carbonic anhydrase 12, ZINC ION, ...
著者	Smirnov, A, Manakova, E, Grazulis, S.
登録日	2021-09-30
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7PUV

Crystal structure of carbonic anhydrase XII with methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate
分子名称:	1,2-ETHANEDIOL, Carbonic anhydrase 12, DI(HYDROXYETHYL)ETHER, ...
著者	Smirnov, A, Manakova, E, Grazulis, S.
登録日	2021-09-30
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7Q0C

Mimic carbonic anhydrase IX in complex with Methyl 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate
分子名称:	ACETATE ION, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
著者	Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S.
登録日	2021-10-14
公開日	2022-01-12
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.12 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

7PP9

Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide
分子名称:	Carbonic anhydrase 12, ZINC ION, methyl 2-chloranyl-4-cyclohexylsulfanyl-5-sulfamoyl-benzoate
著者	Leitans, J, Tars, K, Dvinskis, E.
登録日	2021-09-13
公開日	2022-09-21
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.34 Å)
主引用文献	Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021

4O1X

Crystal structure of human thymidylate synthase double mutant C195S-Y202C
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者	Pozzi, C, Mangani, S.
登録日	2013-12-16
公開日	2015-01-21
最終更新日	2023-03-01
実験手法	X-RAY DIFFRACTION (2.32 Å)
主引用文献	Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife, 11, 2022

1AGP

THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS
分子名称:	C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者	Franken, S.M, Scheidig, A.J, Wittinghofer, A, Goody, R.S.
登録日	1993-03-29
公開日	1994-04-30
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry, 32, 1993

1CLU

H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
分子名称:	3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1
著者	Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K.
登録日	1999-05-03
公開日	1999-05-28
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc.Natl.Acad.Sci.USA, 96, 1999

121P

STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS
分子名称:	H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
著者	Krengel, U, Scheffzek, K, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日	1991-06-06
公開日	1994-01-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.54 Å)
主引用文献	Struktur Und Guanosintriphosphat-Hydrolysemechanismus Des C-Terminal Verkuerzten Menschlichen Krebsproteins P21-H-Ras Thesis, 1991

821P

THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
分子名称:	C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者	Scheidig, A.J, Krengel, U, Pai, E.F, Kabsch, W, Wittinghofer, A, Goody, R.S.
登録日	1993-03-29
公開日	1994-01-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry, 32, 1993

8QW7

Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
分子名称:	(2S,4R)-1-[(2R)-2-[3-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者	Zollman, D, Farnaby, W, Ciulli, A.
登録日	2023-10-18
公開日	2023-12-06
実験手法	X-RAY DIFFRACTION (2.36 Å)
主引用文献	Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023

8QVU

Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex
分子名称:	(2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者	Wijaya, A.J, Zollman, D, Farnaby, W, Ciulli, A.
登録日	2023-10-18
公開日	2023-12-06
実験手法	X-RAY DIFFRACTION (2.24 Å)
主引用文献	Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023

8QW6

Crystal Structure of compound 3 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
分子名称:	(2S,4R)-1-[(2S)-2-[6-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]hexanoylamino]-3,3-dimethyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者	Zollman, D, Farnaby, W, Ciulli, A.
登録日	2023-10-18
公開日	2023-12-06
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023

4JLH

HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
分子名称:	(2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid, HIV-1 Integrase catalytic core domain, SULFATE ION
著者	Feng, L, Kvaratskhelia, M.
登録日	2013-03-12
公開日	2013-05-01
最終更新日	2017-11-15
実験手法	X-RAY DIFFRACTION (2.09 Å)
主引用文献	The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors. J.Biol.Chem., 288, 2013

344D

DETERMINATION BY MAD-DM OF THE STRUCTURE OF THE DNA DUPLEX D(ACGTACG(5-BRU))2 AT 1.46A AND 100K
分子名称:	DNA (5'-D(APCPGPTPAPCPGP(BRU))-3')
著者	Todd, A.R, Adams, A, Powell, H.R, Cardin, C.J.
登録日	1997-08-04
公開日	1997-09-26
最終更新日	2023-08-02
実験手法	X-RAY DIFFRACTION (1.46 Å)
主引用文献	Determination by MAD-DM of the structure of the DNA duplex d[ACGTACG(5-BrU)]2 at 1.46 A and 100 K. Acta Crystallogr.,Sect.D, 55, 1999

8QU8

PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
分子名称:	(2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ...
著者	Fischer, G, Peter, D, Arce-Solano, S.
登録日	2023-10-14
公開日	2023-12-06
最終更新日	2024-01-24
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023

8QUG

KRAS-G12C in Complex with Compound 1
分子名称:	(4S)-2-azanyl-4-methyl-4-[3-[2-[(2S)-2-methyl-1,4-diazepan-1-yl]pyrimidin-4-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者	Fischer, G, Kratochvil, B.
登録日	2023-10-16
公開日	2023-12-06
実験手法	X-RAY DIFFRACTION (1.56 Å)
主引用文献	Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023

<123 4 5 >

全ヒット件数:	124
表示件数:	25
表示順	関連性が高い順