4JLH

HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor

Summary for 4JLH

• Entry DOI: 10.2210/pdb4jlh/pdb
• Related: 1ITG
• Descriptor: HIV-1 Integrase catalytic core domain, (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: integrase, ccd, dde motif, drug resistance, a128t mutation, dimer interface, allosteric inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
• Total number of polymer chains: 1
• Total formula weight: 18699.22

Authors

Feng, L.,Kvaratskhelia, M. (deposition date: 2013-03-12, release date: 2013-05-01, Last modification date: 2017-11-15)

• Primary citation: Feng, L.,Sharma, A.,Slaughter, A.,Jena, N.,Koh, Y.,Shkriabai, N.,Larue, R.C.,Patel, P.A.,Mitsuya, H.,Kessl, J.J.,Engelman, A.,Fuchs, J.R.,Kvaratskhelia, M.; The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.; J.Biol.Chem., 288:15813-15820, 2013; PubMed: 23615903; DOI: 10.1074/jbc.M112.443390

Experimental method

X-RAY DIFFRACTION (2.09 Å)