4JLH
HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIV-1 Integrase catalytic core domain | polymer | 163 | 18182.5 | 1 | UniProt (P12497) Pfam (PF00665) | Human immunodeficiency virus type 1 (HIV-1) | |
| 2 | B (A) | (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid | non-polymer | 420.7 | 1 | Chemie (0L9) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Thr 128 | Ala 1275 | engineered mutation |
| Lys 185 | Phe 1332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18182.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 516.7 | |
| All* | Total formula weight | 18699.2 |
