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Crystal structure of human AF10 PZP bound to histone H3 tail
分子名称:	Histone H3.1,Protein AF-10, ZINC ION
著者	Klein, B.J, Kutateladze, T.G.
登録日	2021-04-20
公開日	2021-08-04
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Nat Commun, 12, 2021

7RGW

Crystal structure of HERC2 DOC domain
分子名称:	DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase HERC2
著者	Liu, J, Tencer, A.H, Kutateladze, T.G.
登録日	2021-07-15
公開日	2022-07-20
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep, 12, 2022

7LKY

Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641
分子名称:	DIMETHYL SULFOXIDE, Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ...
著者	Liu, J, Kutateladze, T.G.
登録日	2021-02-03
公開日	2021-12-15
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J.Med.Chem., 64, 2021

4L7X

Crystal structure of the DIDO PHD finger in complex with H3K4me3
分子名称:	Death-inducer obliterator 1, Histone H3 peptide, ZINC ION
著者	Tong, Q, Gatchalian, J, Kutateladze, T.G.
登録日	2013-06-14
公開日	2013-07-24
実験手法	X-RAY DIFFRACTION (1.35 Å)
主引用文献	Dido3 PHD Modulates Cell Differentiation and Division. Cell Rep, 4, 2013

4L58

Crystal structure of the MLL5 PHD finger in complex with H3K4me3
分子名称:	Histone H3 peptide, Histone-lysine N-methyltransferase MLL5, ZINC ION
著者	Tong, Q, Ali, M, Kutateladze, T.G.
登録日	2013-06-10
公開日	2013-06-26
最終更新日	2013-07-24
実験手法	X-RAY DIFFRACTION (1.48 Å)
主引用文献	Molecular basis for chromatin binding and regulation of MLL5. Proc.Natl.Acad.Sci.USA, 110, 2013

7UHE

Taf14 ET domain in complex with C-terminal tail of Taf2
分子名称:	C-terminal tail of Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 14
著者	Klein, B.J, Kutateladze, T.G.
登録日	2022-03-26
公開日	2022-08-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.66 Å)
主引用文献	Taf2 mediates DNA binding of Taf14. Nat Commun, 13, 2022

7TRL

Crystal structure of human BIRC2 BIR3 domain in complex with histone H3
分子名称:	1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, Histone H3, ...
著者	Klein, B.J, Tencer, A.H, Kutateladze, T.G.
登録日	2022-01-29
公開日	2023-08-02
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.74 Å)
主引用文献	Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat.Struct.Mol.Biol., 30, 2023

7TRM

Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161
分子名称:	1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, LCL-161, ...
著者	Tencer, A.H, Klein, B.J, Kutateladze, T.G.
登録日	2022-01-29
公開日	2023-08-02
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat.Struct.Mol.Biol., 30, 2023

2GP3

Crystal structure of the catalytic core domain of jmjd2a
分子名称:	FE (II) ION, Jumonji domain-containing protein 2A, ZINC ION
著者	Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G.
登録日	2006-04-16
公開日	2006-05-23
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006

2GP5

Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate
分子名称:	2-OXOGLUTARIC ACID, FE (II) ION, Jumonji domain-containing protein 2A, ...
著者	Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G.
登録日	2006-04-16
公開日	2006-05-23
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.28 Å)
主引用文献	Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006

2G6Q

Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide
分子名称:	H3K4Me3 peptide, Inhibitor of growth protein 2, ZINC ION
著者	Pena, P.V, Zhao, R, Kutateladze, T.G.
登録日	2006-02-24
公開日	2006-07-11
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature, 442, 2006

6E83

Solution structure of ZZZ3 ZZ domain in complex with histone H3 tail
分子名称:	Histone H3, ZINC ION, ZZ-type zinc finger-containing protein 3
著者	Zhang, Y, Kutateladze, T.G.
登録日	2018-07-27
公開日	2018-09-19
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation. Nat Commun, 9, 2018

6DS6

Crystal structure of p300 ZZ domain in complex with histone H3 peptide
分子名称:	CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
著者	Zhang, Y, Kutateladze, T.G.
登録日	2018-06-13
公開日	2018-08-29
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3. Nat. Struct. Mol. Biol., 25, 2018

6E86

Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide
分子名称:	H3K4ac, ZINC ION, ZZ-type zinc finger-containing protein 3
著者	Zhang, Y, Kutateladze, T.G.
登録日	2018-07-27
公開日	2018-09-19
最終更新日	2023-11-15
実験手法	SOLUTION NMR
主引用文献	The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation. Nat Commun, 9, 2018

5WLE

Crystal structure of the PPS PHD finger in complex with H3K4me3
分子名称:	H3K4me3 Peptide, Protein partner of snf, isoform A, ...
著者	Klein, B.J, Kutateladze, T.G.
登録日	2017-07-26
公開日	2017-10-04
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.952 Å)
主引用文献	A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure, 25, 2017

5WLF

Crystal structure of the apo PPS PHD finger
分子名称:	GLYCEROL, Protein partner of snf, isoform A, ...
著者	Klein, B.J, Kutateladze, T.G.
登録日	2017-07-26
公開日	2017-10-04
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure, 25, 2017

6WW3

Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail
分子名称:	DI(HYDROXYETHYL)ETHER, GLYCEROL, SUMO1 linked HERC2 ZZ domain (Small ubiquitin-related modifier 1,E3 ubiquitin-protein ligase HERC2), ...
著者	Liu, J, Vann, K.R, Kutateladze, T.G.
登録日	2020-05-07
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.096 Å)
主引用文献	Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020

6WW8

BRD4 Bromodomain 1 in complex with triple CDK4/6-PI3K-BET inhibitor
分子名称:	7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-08
公開日	2020-08-26
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.302 Å)
主引用文献	A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov, 6, 2020

6X7B

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P
分子名称:	7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-29
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.951 Å)
主引用文献	Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020

6X7C

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212
分子名称:	7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-29
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020

6X7D

BRD4 Bromodomain 1 in complex with multi-action inhibitor SF2523P
分子名称:	3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-29
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020

6WW4

Crystal structure of HERC2 ZZ domain in complex with histone H3 tail
分子名称:	GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION
著者	Liu, J, Vann, K.R, Kutateladze, T.G.
登録日	2020-05-07
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.252 Å)
主引用文献	Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020

6MIU

Crystal structure of p62 ZZ domain in complex with Arg-Glu peptide
分子名称:	Sequestosome-1, Arg-Glu peptide chimera, ZINC ION
著者	Ahn, J, Zhang, Y, Kutateladze, T.G.
登録日	2018-09-20
公開日	2018-10-31
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun, 9, 2018

6MJ7

Crystal structure of p62 ZZ domain in complex with free arginine
分子名称:	1,4-DIETHYLENE DIOXIDE, ARGININE, Sequestosome-1, ...
著者	Ahn, J, Zhang, Y, Kutateladze, T.G.
登録日	2018-09-20
公開日	2018-10-31
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.412 Å)
主引用文献	ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun, 9, 2018

7W9V

Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I)
分子名称:	DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
著者	Hatazawa, S, Liu, J, Takizawa, Y, Zandian, M, Negishi, L, Kutateladze, T.G, Kurumizaka, H.
登録日	2021-12-10
公開日	2022-07-13
実験手法	ELECTRON MICROSCOPY (3.95 Å)
主引用文献	Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. Iscience, 25, 2022

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