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Crystal structure of Taf14 YEATS domain G82A mutant
分子名称:	DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14
著者	Klein, B.J, Andrews, F.H, Kutateladze, T.G.
登録日	2018-09-19
公開日	2018-11-14
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun, 9, 2018

6MIQ

Crystal structure of Taf14 YEATS domain in complex with histone H3K9bu
分子名称:	Histone H3K9bu, Transcription initiation factor TFIID subunit 14
著者	Klein, B.J, Andrews, F.H, Vann, K.R, Kutateladze, T.G.
登録日	2018-09-19
公開日	2018-11-14
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun, 9, 2018

6MIL

Crystal structure of AF9 YEATS domain in complex with histone H3K9bu
分子名称:	DI(HYDROXYETHYL)ETHER, Histone H3K9bu, MALONATE ION, ...
著者	Vann, K.R, Klein, B.J, Kutateladze, T.G.
登録日	2018-09-19
公開日	2018-11-14
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	Structural insights into the pi-pi-pi stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun, 9, 2018

7RGW

Crystal structure of HERC2 DOC domain
分子名称:	DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase HERC2
著者	Liu, J, Tencer, A.H, Kutateladze, T.G.
登録日	2021-07-15
公開日	2022-07-20
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep, 12, 2022

4L7X

Crystal structure of the DIDO PHD finger in complex with H3K4me3
分子名称:	Death-inducer obliterator 1, Histone H3 peptide, ZINC ION
著者	Tong, Q, Gatchalian, J, Kutateladze, T.G.
登録日	2013-06-14
公開日	2013-07-24
実験手法	X-RAY DIFFRACTION (1.35 Å)
主引用文献	Dido3 PHD Modulates Cell Differentiation and Division. Cell Rep, 4, 2013

4L58

Crystal structure of the MLL5 PHD finger in complex with H3K4me3
分子名称:	Histone H3 peptide, Histone-lysine N-methyltransferase MLL5, ZINC ION
著者	Tong, Q, Ali, M, Kutateladze, T.G.
登録日	2013-06-10
公開日	2013-06-26
最終更新日	2013-07-24
実験手法	X-RAY DIFFRACTION (1.48 Å)
主引用文献	Molecular basis for chromatin binding and regulation of MLL5. Proc.Natl.Acad.Sci.USA, 110, 2013

6DS6

Crystal structure of p300 ZZ domain in complex with histone H3 peptide
分子名称:	CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
著者	Zhang, Y, Kutateladze, T.G.
登録日	2018-06-13
公開日	2018-08-29
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3. Nat. Struct. Mol. Biol., 25, 2018

6E86

Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide
分子名称:	H3K4ac, ZINC ION, ZZ-type zinc finger-containing protein 3
著者	Zhang, Y, Kutateladze, T.G.
登録日	2018-07-27
公開日	2018-09-19
最終更新日	2023-11-15
実験手法	SOLUTION NMR
主引用文献	The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation. Nat Commun, 9, 2018

6E83

Solution structure of ZZZ3 ZZ domain in complex with histone H3 tail
分子名称:	Histone H3, ZINC ION, ZZ-type zinc finger-containing protein 3
著者	Zhang, Y, Kutateladze, T.G.
登録日	2018-07-27
公開日	2018-09-19
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation. Nat Commun, 9, 2018

2GP5

Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate
分子名称:	2-OXOGLUTARIC ACID, FE (II) ION, Jumonji domain-containing protein 2A, ...
著者	Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G.
登録日	2006-04-16
公開日	2006-05-23
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.28 Å)
主引用文献	Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006

2GP3

Crystal structure of the catalytic core domain of jmjd2a
分子名称:	FE (II) ION, Jumonji domain-containing protein 2A, ZINC ION
著者	Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G.
登録日	2006-04-16
公開日	2006-05-23
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006

2G6Q

Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide
分子名称:	H3K4Me3 peptide, Inhibitor of growth protein 2, ZINC ION
著者	Pena, P.V, Zhao, R, Kutateladze, T.G.
登録日	2006-02-24
公開日	2006-07-11
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature, 442, 2006

6WW3

Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail
分子名称:	DI(HYDROXYETHYL)ETHER, GLYCEROL, SUMO1 linked HERC2 ZZ domain (Small ubiquitin-related modifier 1,E3 ubiquitin-protein ligase HERC2), ...
著者	Liu, J, Vann, K.R, Kutateladze, T.G.
登録日	2020-05-07
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.096 Å)
主引用文献	Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020

6WW8

BRD4 Bromodomain 1 in complex with triple CDK4/6-PI3K-BET inhibitor
分子名称:	7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-08
公開日	2020-08-26
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.302 Å)
主引用文献	A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov, 6, 2020

6X7D

BRD4 Bromodomain 1 in complex with multi-action inhibitor SF2523P
分子名称:	3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-29
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020

6WW4

Crystal structure of HERC2 ZZ domain in complex with histone H3 tail
分子名称:	GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION
著者	Liu, J, Vann, K.R, Kutateladze, T.G.
登録日	2020-05-07
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.252 Å)
主引用文献	Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure, 28, 2020

6X7B

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P
分子名称:	7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-29
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.951 Å)
主引用文献	Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020

6X7C

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212
分子名称:	7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4
著者	Vann, K.R, Kutateladze, T.G.
登録日	2020-05-29
公開日	2020-08-05
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020

7TRL

Crystal structure of human BIRC2 BIR3 domain in complex with histone H3
分子名称:	1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, Histone H3, ...
著者	Klein, B.J, Tencer, A.H, Kutateladze, T.G.
登録日	2022-01-29
公開日	2023-08-02
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.74 Å)
主引用文献	Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat.Struct.Mol.Biol., 30, 2023

7TRM

Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161
分子名称:	1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, LCL-161, ...
著者	Tencer, A.H, Klein, B.J, Kutateladze, T.G.
登録日	2022-01-29
公開日	2023-08-02
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat.Struct.Mol.Biol., 30, 2023

7UHE

Taf14 ET domain in complex with C-terminal tail of Taf2
分子名称:	C-terminal tail of Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 14
著者	Klein, B.J, Kutateladze, T.G.
登録日	2022-03-26
公開日	2022-08-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.66 Å)
主引用文献	Taf2 mediates DNA binding of Taf14. Nat Commun, 13, 2022

6O7G

Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide
分子名称:	Histone H4, Histone-lysine N-methyltransferase 2D, ZINC ION
著者	Zhang, Y, Kutateladze, T.G.
登録日	2019-03-07
公開日	2019-05-22
最終更新日	2023-11-15
実験手法	SOLUTION NMR
主引用文献	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nat Commun, 10, 2019

6OIE

The double PHD finger (DPF) of MORF in complex with histone H3K14cr
分子名称:	Histone H3.1t peptide, Histone acetyltransferase KAT6B, ZINC ION
著者	Klein, B.J, Kutateladze, T.G.
登録日	2019-04-09
公開日	2019-11-20
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.075 Å)
主引用文献	Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Nat Commun, 10, 2019

7TV0

Crystal structure of BRD4 bromodomain 1 in complex with dual-acetylated SARS-CoV-2 E
分子名称:	Bromodomain-containing protein 4, Envelope small membrane protein
著者	Vann, K.R, Holt, T.A, Kutateladze, T.G.
登録日	2022-02-03
公開日	2022-07-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection. Structure, 30, 2022

7TUQ

Crystal structure of BRD4 bromodomain 1 in complex with monoacetylated SARS-CoV-2 E
分子名称:	Bromodomain-containing protein 4, Envelope small membrane protein
著者	Vann, K.R, Kutateladze, T.G.
登録日	2022-02-03
公開日	2022-07-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.68 Å)
主引用文献	Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection. Structure, 30, 2022

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