2N8I
| Solution NMR Structure of Designed Protein DA05, Northeast Structural Genomics Consortium (NESG) Target OR626 | 分子名称: | Designed Protein DA05 | 著者 | Xu, X, Eletsky, A, Federizon, J.F, Jacobs, T.M, Kuhlman, B, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2015-10-15 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Design of structurally distinct proteins using strategies inspired by evolution. Science, 352, 2016
|
|
1MHX
| Crystal Structures of the redesigned protein G variant NuG1 | 分子名称: | immunoglobulin-binding protein G | 著者 | Nauli, S, Kuhlman, B, Le Trong, I, Stenkamp, R.E, Teller, D.C, Baker, D. | 登録日 | 2002-08-21 | 公開日 | 2002-09-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures and increased stabilization of the protein G variants with switched folding pathways NuG1 and NuG2 Protein Sci., 11, 2002
|
|
2LCH
| Solution NMR Structure of a Protein With a Redesigned Hydrophobic Core, Northeast Structural Genomics Consortium Target OR38 | 分子名称: | Protein OR38 | 著者 | Mills, J.L, Murphy, G, Miley, M, Machius, M, Kuhlman, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-04-29 | 公開日 | 2011-05-25 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of a Protein With a Redesigned Hydrophobic Core, Northeast Structural Genomics Consortium Target OR38 To be Published
|
|
3V1F
| Crystal structure of de novo designed MID1-zinc H35E mutant | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Computational design, ... | 著者 | Der, B.S, Machius, M, Miley, M.J, Kuhlman, B. | 登録日 | 2011-12-09 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.151 Å) | 主引用文献 | Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J.Am.Chem.Soc., 134, 2012
|
|
3ZY7
| Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer | 分子名称: | AP-1 COMPLEX SUBUNIT GAMMA-1, DI(HYDROXYETHYL)ETHER, ISOPROPYL ALCOHOL | 著者 | Stranges, P.B, Machius, M, Miley, M.J, Tripathy, A, Kuhlman, B. | 登録日 | 2011-08-17 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Computational Design of a Symmetric Homodimer Using Beta-Strand Assembly. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3V1C
| Crystal structure of de novo designed MID1-zinc | 分子名称: | Computational design, MID1-zinc, L(+)-TARTARIC ACID, ... | 著者 | Der, B.S, Machius, M, Miley, M.J, Kuhlman, B. | 登録日 | 2011-12-09 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.129 Å) | 主引用文献 | Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J.Am.Chem.Soc., 134, 2012
|
|
3V1D
| Crystal structure of de novo designed MID1-cobalt | 分子名称: | COBALT (II) ION, Computational design, MID1-cobalt, ... | 著者 | Der, B.S, Machius, M, Miley, M.J, Kuhlman, B. | 登録日 | 2011-12-09 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.239 Å) | 主引用文献 | Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J.Am.Chem.Soc., 134, 2012
|
|
3V1A
| Crystal structure of de novo designed MID1-apo1 | 分子名称: | Computational design, MID1-apo1 | 著者 | Der, B.S, Machius, M, Miley, M.J, Kuhlman, B. | 登録日 | 2011-12-09 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J.Am.Chem.Soc., 134, 2012
|
|
3V1E
| Crystal structure of de novo designed MID1-zinc H12E mutant | 分子名称: | Computational design, MID1-zinc H12E mutant, ZINC ION | 著者 | Der, B.S, Machius, M, Miley, M.J, Kuhlman, B. | 登録日 | 2011-12-09 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.073 Å) | 主引用文献 | Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J.Am.Chem.Soc., 134, 2012
|
|
3V1B
| Crystal structure of de novo designed MID1-apo2 | 分子名称: | Computational design, MID1-apo2, GLYCEROL | 著者 | Der, B.S, Machius, M, Miley, M.J, Kuhlman, B. | 登録日 | 2011-12-09 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J.Am.Chem.Soc., 134, 2012
|
|
4LLD
| Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A | 分子名称: | Ig gamma-1 chain C region, Ig lambda-2 chain C region | 著者 | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | 登録日 | 2013-07-09 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
|
|
4LLY
| Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A | 分子名称: | GLYCEROL, MAGNESIUM ION, light chain Clambda, ... | 著者 | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | 登録日 | 2013-07-09 | 公開日 | 2014-01-29 | 最終更新日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
|
|
4LLW
| Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A | 分子名称: | SULFATE ION, light chain Clambda, mutated Pertuzumab Fab heavy chain | 著者 | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | 登録日 | 2013-07-09 | 公開日 | 2014-01-29 | 最終更新日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
|
|
4LLQ
| Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, mutated CH1, mutated light chain Clambda | 著者 | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | 登録日 | 2013-07-09 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
|
|
4LLU
| Structure of Pertuzumab Fab with light chain Clambda at 2.16A | 分子名称: | ACETATE ION, Light chain CLAMBDA, PERTUZUMAB FAB Heavy chain, ... | 著者 | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | 登録日 | 2013-07-09 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
|
|
4LLM
| Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A | 分子名称: | Ig gamma-1 chain C region, Ig lambda-2 chain C region | 著者 | Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S. | 登録日 | 2013-07-09 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat.Biotechnol., 32, 2014
|
|
5E6G
| |
5DJ2
| Fc Heterodimer Design 7.4 Y407A + T366V/K409V | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Secrist, E, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-01 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DJD
| Fc Heterodimer Design 5.1 T366V + Y407F | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-02 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DK2
| Fc Heterodimer E356K/D399K + K392D/K409D | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-02 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DJZ
| Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-02 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DVN
| Fc K392D/K409D homodimer | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-21 | 公開日 | 2016-03-30 | 最終更新日 | 2016-07-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DJ6
| Fc Heterodimer Design 6.1 F405W/Y407A + T366M | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-01 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DJ8
| Fc Heterodimer Design 7.7 D399M/Y407A + T366V/K409I | 分子名称: | Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Secrist, E, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-01 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|
5DJC
| Fc Heterodimer Design 8.1 L368V/Y407A + T366V/K409F | 分子名称: | Fc-III peptide, IODIDE ION, Ig gamma-1 chain C region, ... | 著者 | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Secrist, E, Demarest, S.J, Kuhlman, B. | 登録日 | 2015-09-01 | 公開日 | 2016-03-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
|
|