5DK2

Fc Heterodimer E356K/D399K + K392D/K409D

Summary for 5DK2

Entry DOI	10.2210/pdb5dk2/pdb
Related	5DI8 5DJ0 5DJ2 5DJ6 5DJ8 5DJA 5DJC 5DJD 5DJX 5DJY 5DJZ 5DK0 5DVK 5DVL 5DVM 5DVN 5DVO
Descriptor	Ig gamma-1 chain C region, Fc-III peptide, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	heterodimer, immunoglobulin, ch3, fc, bispecific antibody, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P01857 P01857
Total number of polymer chains	5
Total formula weight	110817.09
Authors	Atwell, S.,Leaver-Fay, A.,Froning, K.J.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Dhanani, S.H.,Chamberlain, A.K.,Fitchett, J.R.,Gutierrez, B.,Hendle, J.,Demarest, S.J.,Kuhlman, B. (deposition date: 2015-09-02, release date: 2016-03-30, Last modification date: 2020-07-29)
Primary citation	Leaver-Fay, A.,Froning, K.J.,Atwell, S.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Hassanali, S.,Chamberlain, A.K.,Fitchett, J.R.,Demarest, S.J.,Kuhlman, B. Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24:641-651, 2016 Cited by PubMed: 26996964 DOI: 10.1016/j.str.2016.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation