5DJX
Fc Heterodimer Design 2.9 L368M/K370E + E357A/S364G
Summary for 5DJX
Entry DOI | 10.2210/pdb5djx/pdb |
Related | 5DI8 5DJ0 5DJ2 5DJ6 5DJ8 5DJA 5DJC 5DJD 5DJY 5DJZ 5DK0 5DK2 |
Descriptor | Ig gamma-1 chain C region, Fc-III peptide, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | heterodimer, immunoglobulin, ch3, fc, bispecific antibody, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P01857 P01857 |
Total number of polymer chains | 6 |
Total formula weight | 113807.15 |
Authors | Atwell, S.,Leaver-Fay, A.,Froning, K.J.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Dhanani, S.H.,Chamberlain, A.K.,Fitchett, J.R.,Gutierrez, B.,Hendle, J.,Demarest, S.J.,Kuhlman, B. (deposition date: 2015-09-02, release date: 2016-03-30, Last modification date: 2020-07-29) |
Primary citation | Leaver-Fay, A.,Froning, K.J.,Atwell, S.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Hassanali, S.,Chamberlain, A.K.,Fitchett, J.R.,Demarest, S.J.,Kuhlman, B. Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24:641-651, 2016 Cited by PubMed: 26996964DOI: 10.1016/j.str.2016.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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