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Crystal structure of the SARS-CoV-2 S RBD in complex with pT1611 scFV
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1611 single-chain Fv
著者	Hansen, G, Ssebyatika, G.L, Krey, T.
登録日	2022-10-27
公開日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

5NPH

Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5
分子名称:	Genome polyprotein, Heavy chain of Fab fragment derived from non-neutralizing antibody DAO5, Light chain of Fab fragment derived from non-neutralizing antibody DAO5
著者	Vasiliauskaite, I, Rey, F.A, Krey, T.
登録日	2017-04-16
公開日	2017-05-24
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017

8PHI

Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib
分子名称:	2-(2-METHOXYETHOXY)ETHANOL, 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, CALCIUM ION, ...
著者	Rajak, M, Krey, T.
登録日	2023-06-19
公開日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.289 Å)
主引用文献	Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor. Nat Commun, 15, 2024

5NPI

Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5
分子名称:	Epitope peptide, Single chain variable fragment of the non-neutralizing antibody DAO5
著者	Vasiliauskaite, I, Rey, F.A, Krey, T.
登録日	2017-04-16
公開日	2017-05-24
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017

7NXE

Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide
分子名称:	Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15
著者	Ssebyatika, G, Krey, T.
登録日	2021-03-18
公開日	2021-06-09
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation. Plos Pathog., 17, 2021

6GFC

Structure of the BTB/POZ domain of human 90K
分子名称:	Galectin-3-binding protein
著者	Ssebyatika, G, Krey, T.
登録日	2018-04-29
公開日	2018-05-09
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific. J. Virol., 92, 2018

6GFB

Structure of the BTB/POZ domain of human 90K
分子名称:	Galectin-3-binding protein, ZINC ION
著者	Ssebyatika, G, Krey, T.
登録日	2018-04-29
公開日	2018-05-09
最終更新日	2018-07-11
実験手法	X-RAY DIFFRACTION (2.08 Å)
主引用文献	The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific. J. Virol., 92, 2018

3U6R

Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 single chain FV fragment 1:7
分子名称:	Antibody 1:7 (Heavy chain), Antibody 1:7 (Light chain), SULFATE ION
著者	Gilmartin, A.A, Lamp, B, Ruemenapf, T, Persson, A.A, Rey, F.A, Krey, T.
登録日	2011-10-12
公開日	2012-01-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.67 Å)
主引用文献	High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells. Protein Eng.Des.Sel., 25, 2012

8PMX

rat HEV P domain in complex with glycan-sensitive nAb p60.12
分子名称:	Fab p60.12-HC, Fab p60.12-LC, Pro-secreted protein ORF2
著者	Ssebyatika, G, Krey, T.
登録日	2023-06-29
公開日	2024-07-10
実験手法	X-RAY DIFFRACTION (3.922 Å)
主引用文献	A novel class of broadly neutralizing hepatitis E virus-specific human antibodies To Be Published

8PN0

HEV gt3 P domain in complex with glycan-sensitive nAb p60.12
分子名称:	Capsid protein, Fab_p60.12-HC, Fab_p60.12-LC
著者	Ssebyatika, G, Krey, T.
登録日	2023-06-29
公開日	2024-07-10
実験手法	X-RAY DIFFRACTION (2.072 Å)
主引用文献	A novel class of broadly neutralizing hepatitis E virus-specific human antibodies To Be Published

8PMZ

HEV gt3 P domain in complex with glycan-insensitive nAb p61.15
分子名称:	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-secreted protein ORF2, scFv_p61.15
著者	Ssebyatika, G, Krey, T.
登録日	2023-06-29
公開日	2024-07-10
実験手法	X-RAY DIFFRACTION (1.912 Å)
主引用文献	A novel class of broadly neutralizing hepatitis E virus-specific human antibodies To Be Published

8PMW

HEV gt3 P domain in complex with glycan-sensitive nAb p60.1
分子名称:	ACETATE ION, Capsid protein, SULFATE ION, ...
著者	Ssebyatika, G, Krey, T.
登録日	2023-06-29
公開日	2024-07-10
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	A novel class of broadly neutralizing hepatitis E virus-specific human antibodies To Be Published

8PMY

HEV gt3 P domain in complex with glycan-insensitive nAb p60.15
分子名称:	Capsid protein, ZINC ION, scFv_p60.15
著者	Ssebyatika, G, Krey, T.
登録日	2023-06-29
公開日	2024-07-10
実験手法	X-RAY DIFFRACTION (2.406 Å)
主引用文献	A novel class of broadly neutralizing hepatitis E virus-specific human antibodies To Be Published

5MF1

Crystal structure of a C-terminally truncated trimeric ectodomain of the Chlamydomonas reinhardtii gamete fusion protein HAP2
分子名称:	2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion protein HAP2/GCS1
著者	Fedry, J, Rey, F.A, Krey, T.
登録日	2016-11-17
公開日	2017-03-08
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein. Cell, 168, 2017

5FGC

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.8
分子名称:	Anti-HCV E2 Fab HC33.8 heavy chain, Anti-HCV E2 Fab HC33.8 light chain, Genome polyprotein
著者	Girard-Blanc, C, Rey, F.A, Krey, T.
登録日	2015-12-20
公開日	2016-01-20
最終更新日	2016-03-09
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. J.Virol., 90, 2016

5FGB

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.4
分子名称:	Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, GLYCEROL, ...
著者	Girard-Blanc, C, Rey, F.A, Krey, T.
登録日	2015-12-20
公開日	2016-01-20
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. J.Virol., 90, 2016

7NXP

Structure of the C-terminal domain of the pUL77 capsid protein from human cytomegalovirus (HCMV)
分子名称:	Capsid vertex component 2, GLYCEROL
著者	Naniima, P, Legrand, P, Krey, T.
登録日	2021-03-19
公開日	2021-10-13
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.896 Å)
主引用文献	Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021

7NXQ

Structure of the pentameric C-terminal domain of the capsid protein from Kaposi's sarcoma-associated herpesvirus (KSHV)
分子名称:	ACETATE ION, Capsid vertex component 2
著者	Naniima, P, Legrand, P, Krey, T.
登録日	2021-03-19
公開日	2021-10-13
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.422 Å)
主引用文献	Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021

7NXR

Structure of the C-terminal domain of the pORF19 capsid protein from murid gammaherpesvirus 68 (MuHV-68)
分子名称:	Capsid vertex component 2
著者	Naniima, P, Legrand, P, Krey, T.
登録日	2021-03-19
公開日	2021-10-13
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021

5NPJ

Structure of the Hepatitis C virus strain JFH1 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5
分子名称:	Epitope peptide, Single chain variable fragment of the non-neutralizing antibody DAO5
著者	Vasiliauskaite, I, Rey, F.A, Krey, T.
登録日	2017-04-16
公開日	2017-05-24
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017

5OW3

Crystal structure of a C-terminally truncated trimeric ectodomain of the Arabidopsis thaliana gamete fusion protein HAP2
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ...
著者	Fedry, J, Legrand, P, Rey, F.A, Krey, T.
登録日	2017-08-30
公開日	2018-08-22
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes. PLoS Biol., 16, 2018

5OW4

Crystal structure of a protease-resistant fragment of the Trypanosoma cruzi gamete fusion protein HAP2 ectodomain
分子名称:	Uncharacterized protein
著者	Fedry, J, Rey, F.A, Krey, T.
登録日	2017-08-30
公開日	2018-08-22
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes. PLoS Biol., 16, 2018

7RFB

Crystal structure of broadly neutralizing antibody mAb1198 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Flyak, A.I, Bjorkman, P.J.
登録日	2021-07-14
公開日	2022-01-12
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization. Immunity, 55, 2022

7RFC

Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Flyak, A.I, Bjorkman, P.J.
登録日	2021-07-14
公開日	2022-01-12
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.24 Å)
主引用文献	Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization. Immunity, 55, 2022

6E18

Crystal structure of Chlamydomonas reinhardtii HAP2 ectodomain provides structural insights of functional loops in green algae.
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者	Baquero, E, Legrand, P, Rey, F.A.
登録日	2018-07-09
公開日	2018-11-07
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies. Structure, 27, 2019

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