7RFC

Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

Summary for 7RFC

Entry DOI	10.2210/pdb7rfc/pdb
Descriptor	mAb1382 Heavy Chain, mAb1382 Light Chain, envelope glycoprotein E2, ... (7 entities in total)
Functional Keywords	hcv glycoprotein, broadly neutralizing antibodies, viral protein-immune system complex, viral protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	160874.76
Authors	Flyak, A.I.,Bjorkman, P.J. (deposition date: 2021-07-14, release date: 2022-01-12, Last modification date: 2023-10-18)
Primary citation	Weber, T.,Potthoff, J.,Bizu, S.,Labuhn, M.,Dold, L.,Schoofs, T.,Horning, M.,Ercanoglu, M.S.,Kreer, C.,Gieselmann, L.,Vanshylla, K.,Langhans, B.,Janicki, H.,Stroh, L.J.,Knops, E.,Nierhoff, D.,Spengler, U.,Kaiser, R.,Bjorkman, P.J.,Krey, T.,Bankwitz, D.,Pfeifer, N.,Pietschmann, T.,Flyak, A.I.,Klein, F. Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization. Immunity, 55:341-354.e7, 2022 Cited by PubMed: 34990590 DOI: 10.1016/j.immuni.2021.12.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.24 Å)

Structure validation