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4R2Y
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BU of 4r2y by Molmil
Crystal structure of APC11 RING domain
分子名称: Anaphase-promoting complex subunit 11, ZINC ION
著者Brown, N.G, Watson, E.R, Weissmann, F, Jarvis, M.A, Vanderlinden, R, Grace, C.R.R, Frye, J.J, Dube, P, Qiao, R, Petzold, G, Cho, S.E, Alsharif, O, Bao, J, Zheng, J, Nourse, A, Kurinov, I, Peters, J.M, Stark, H, Schulman, B.A.
登録日2014-08-13
公開日2014-10-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.755 Å)
主引用文献Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly.
Mol.Cell, 56, 2014
3O6B
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BU of 3o6b by Molmil
A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB) low resolution
分子名称: Cell division control protein 53, Defective in cullin neddylation protein 1
著者Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
登録日2010-07-28
公開日2010-09-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3O2U
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BU of 3o2u by Molmil
S. cerevisiae Ubc12
分子名称: GLYCEROL, NEDD8-conjugating enzyme UBC12
著者Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
登録日2010-07-22
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.003 Å)
主引用文献A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
4PXA
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BU of 4pxa by Molmil
DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION
著者Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
登録日2014-03-22
公開日2015-03-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
4PX9
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BU of 4px9 by Molmil
DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X
著者Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
登録日2014-03-22
公開日2015-03-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
6OB1
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BU of 6ob1 by Molmil
Structure of WHB in complex with Ubiquitin Variant
分子名称: Anaphase-promoting complex subunit 2, Ubiquitin
著者Edmond, R.W, Grace, C.R.
登録日2019-03-19
公開日2019-08-14
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
3O2P
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BU of 3o2p by Molmil
A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB)
分子名称: Cell division control protein 53, Defective in cullin neddylation protein 1, GLYCEROL
著者Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
登録日2010-07-22
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.233 Å)
主引用文献A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3RTR
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BU of 3rtr by Molmil
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
分子名称: Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
著者Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A.
登録日2011-05-03
公開日2011-07-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
2M5B
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BU of 2m5b by Molmil
The NMR structure of the BID-BAK complex
分子名称: Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB
著者Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R.
登録日2013-02-19
公開日2013-04-17
最終更新日2024-10-09
実験手法SOLUTION NMR
主引用文献BID-induced structural changes in BAK promote apoptosis.
Nat.Struct.Mol.Biol., 20, 2013
2RMI
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BU of 2rmi by Molmil
3D NMR structure of astressin
分子名称: astressin
著者Royappa, G.C.R, Cervini, L, Gulyas, J, Rivier, J, Riek, R.
登録日2007-10-17
公開日2007-10-30
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide
Biopolymers, 87, 2007
6D74
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BU of 6d74 by Molmil
Direct Activation of the Executioner Domain of MLKL by a Select Repertoire of Inositol Phosphates
分子名称: Mixed lineage kinase domain-like protein
著者Royappa, G.C, McNamara, D.E, Moldoveanu, T.
登録日2018-04-24
公開日2019-05-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
Cell Chem Biol, 26, 2019
4HNJ
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BU of 4hnj by Molmil
Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution
分子名称: Bcl-2-binding component 3, Bcl-2-like protein 1
著者Fisher, J.C, Yun, M.K, White, S.W.
登録日2012-10-19
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
7M5A
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BU of 7m5a by Molmil
Crystal Structure of human BAK in complex with W3W5_BID
分子名称: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
7M5B
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BU of 7m5b by Molmil
Crystal Structure of human BAK in complex with M3W5_BID
分子名称: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer, COPPER (II) ION
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
7M5C
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BU of 7m5c by Molmil
Crystal Structure of human BAK in complex with WT BAK BH3 peptide
分子名称: Bcl-2 homologous antagonist/killer, COPPER (II) ION, SULFATE ION
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
6AXD
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BU of 6axd by Molmil
Structures of REV1 UBM2 domain complex with ubiquitin and with the first small-molecule that inhibits the REV1 UBM2-ubiquitin interaction
分子名称: DNA repair protein REV1
著者Fujii, N, Vanarotti, M.
登録日2017-09-06
公開日2018-06-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
J. Mol. Biol., 430, 2018
6ASR
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BU of 6asr by Molmil
REV1 UBM2 domain complex with ubiquitin
分子名称: DNA repair protein REV1, NICKEL (II) ION, Ubiquitin
著者Miller, D.J.
登録日2017-08-25
公開日2018-06-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.356 Å)
主引用文献Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
J. Mol. Biol., 430, 2018
8UR6
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BU of 8ur6 by Molmil
Cryo-EM reconstruction of Staphylococcus aureus oleate hydratase (OhyA) dimer with a disordered C-terminal membrane-association domain
分子名称: Oleate hydratase
著者Oldham, M.L, Qayyum, M.Z.
登録日2023-10-25
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer.
J.Biol.Chem., 300, 2024
8UR3
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BU of 8ur3 by Molmil
Cryo-EM reconstruction of Staphylococcus aureus Oleate hydratase (OhyA) dimer with an ordered C-terminal membrane-association domain
分子名称: Oleate hydratase
著者Oldham, M.L, Qayyum, M.Z.
登録日2023-10-25
公開日2024-01-10
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.61 Å)
主引用文献The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer.
J.Biol.Chem., 300, 2024
7SG3
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BU of 7sg3 by Molmil
The X-ray crystal structure of the Staphylococcus aureus Fatty Acid Kinase B1 mutant A121I-A158L to 2.35 Angstrom resolution (Open form chain A, Palmitate bound)
分子名称: Fatty Acid Kinase B1, PALMITIC ACID
著者Cuypers, M.G, Gullett, J.M, Rock, C.O, White, S.W.
登録日2021-10-04
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes.
J.Biol.Chem., 298, 2022
7SCL
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BU of 7scl by Molmil
The X-ray crystal structure of Staphylococcus aureus Fatty Acid Kinase B1 (FakB1) mutant R173A in complex with Palmitate to 1.60 Angstrom resolution
分子名称: Fatty Acid Kinase B1, GLYCEROL, PALMITIC ACID
著者Cuypers, M.G, Gullett, J.M, Subramanian, C, Rock, C.O, White, S.W.
登録日2021-09-28
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes.
J.Biol.Chem., 298, 2022
4N8M
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BU of 4n8m by Molmil
Structural polymorphism in the N-terminal oligomerization domain of NPM1
分子名称: COBALT (II) ION, Nucleophosmin
著者Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W.
登録日2013-10-17
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Proc.Natl.Acad.Sci.USA, 111, 2014
6MH9
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BU of 6mh9 by Molmil
The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein A121I mutant to 2.02 Angstrom resolution
分子名称: Fatty Acid Kinase (Fak) B1 protein, PALMITIC ACID
著者Cuypers, M.G, Ericson, M, Subramanian, C, White, S.W, Rock, C.O.
登録日2018-09-17
公開日2019-11-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes.
J.Biol.Chem., 298, 2022
6NM1
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BU of 6nm1 by Molmil
The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein A158L mutant to 2.33 Angstrom resolution exhibits a conformation change compared to the wild type form
分子名称: Fatty acid Kinase (Fak) B1 protein, MYRISTIC ACID
著者Cuypers, M.G, Gullett, J.M, Subramanian, C, Ericson, M, White, S.W, Rock, C.O.
登録日2019-01-10
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes.
J.Biol.Chem., 298, 2022
5L9U
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BU of 5l9u by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
登録日2016-06-11
公開日2016-09-14
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (6.4 Å)
主引用文献Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016

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