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3CN0
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BU of 3cn0 by Molmil
Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene
分子名称: 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2008-03-24
公開日2008-10-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51, 2008
3CN4
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BU of 3cn4 by Molmil
Human transthyretin (TTR) in complex with N-(3,5-Dibromo-4-hydroxyphenyl)benzamide
分子名称: N-(3,5-dibromo-4-hydroxyphenyl)benzamide, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2008-03-24
公開日2008-10-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51, 2008
3CN1
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BU of 3cn1 by Molmil
Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxystilbene
分子名称: 2,6-dibromo-4-[(E)-2-phenylethenyl]phenol, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2008-03-24
公開日2008-10-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51, 2008
3CN2
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BU of 3cn2 by Molmil
Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl
分子名称: 3,5-dibromobiphenyl-4-ol, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2008-03-24
公開日2008-10-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51, 2008
3P3U
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BU of 3p3u by Molmil
Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole
分子名称: 4-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2010-10-05
公開日2011-08-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3, 2011
3P3T
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BU of 3p3t by Molmil
Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole
分子名称: 4-[3-(2-fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2010-10-05
公開日2011-08-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3, 2011
3TCT
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BU of 3tct by Molmil
Structure of wild-type TTR in complex with tafamidis
分子名称: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin
著者Connelly, S, Kelly, J.W, Wilson, I.A.
登録日2011-08-09
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
Proc.Natl.Acad.Sci.USA, 109, 2012
3P3S
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BU of 3p3s by Molmil
Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one
分子名称: (5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2010-10-05
公開日2011-08-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3, 2011
3P3R
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BU of 3p3r by Molmil
Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone
分子名称: (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2010-10-05
公開日2011-08-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3, 2011
4FI7
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BU of 4fi7 by Molmil
Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
分子名称: 3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin
著者Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W.
登録日2012-06-08
公開日2013-02-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.402 Å)
主引用文献Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
4FI6
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BU of 4fi6 by Molmil
Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
分子名称: 3-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin
著者Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W.
登録日2012-06-08
公開日2013-02-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
4FI8
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BU of 4fi8 by Molmil
Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
分子名称: 4-bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin
著者Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W.
登録日2012-06-08
公開日2013-02-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
4HIS
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BU of 4his by Molmil
The Structure of V122I Mutant Transthyretin in Complex with Tafamidis
分子名称: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin
著者Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A.
登録日2012-10-11
公開日2013-06-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HJU
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BU of 4hju by Molmil
Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide
分子名称: N-{3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}prop-2-enamide, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2012-10-14
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
4HJT
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BU of 4hjt by Molmil
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide
分子名称: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2012-10-14
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
4HIQ
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BU of 4hiq by Molmil
The Structure of V122I Mutant Transthyretin in Complex with AG10
分子名称: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin
著者Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A.
登録日2012-10-11
公開日2013-06-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HJS
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BU of 4hjs by Molmil
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide
分子名称: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2012-10-14
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
5ME0
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BU of 5me0 by Molmil
Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112
分子名称: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S.
登録日2016-11-14
公開日2017-01-11
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (13.5 Å)
主引用文献Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
5ME1
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BU of 5me1 by Molmil
Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112
分子名称: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S.
登録日2016-11-14
公開日2017-01-11
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (13.5 Å)
主引用文献Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
7AFI
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BU of 7afi by Molmil
Bacterial 30S ribosomal subunit assembly complex state C (body domain)
分子名称: 16SrRNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
著者Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Kaminishi, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S.
登録日2020-09-19
公開日2021-07-07
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021
7AFN
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BU of 7afn by Molmil
Bacterial 30S ribosomal subunit assembly complex state B (head domain)
分子名称: 16SrRNA (head domain of the 30S ribosome), 30S ribosomal protein S10, 30S ribosomal protein S13, ...
著者Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Kaminishi, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S.
登録日2020-09-19
公開日2021-07-07
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.86 Å)
主引用文献A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021
7AFD
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BU of 7afd by Molmil
Bacterial 30S ribosomal subunit assembly complex state A (head domain)
分子名称: 16SrRNA of the head domain (residue C931 to G1386), 30S ribosomal protein S10, 30S ribosomal protein S13, ...
著者Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Kaminishi, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S.
登録日2020-09-19
公開日2021-07-07
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021
7AFL
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BU of 7afl by Molmil
Bacterial 30S ribosomal subunit assembly complex state D (multibody refinement for body domain of 30S ribosome)
分子名称: 16SrRNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
著者Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Kaminishi, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S.
登録日2020-09-19
公開日2021-07-07
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021
7AF8
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BU of 7af8 by Molmil
Bacterial 30S ribosomal subunit assembly complex state E (head domain)
分子名称: 16SrRNA (head domain of the 30S ribosome, 30S ribosomal protein S10, 30S ribosomal protein S13, ...
著者Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Lopez-Alonso, J, Kaminishi, T, Capuni, R, Astigarraga, E, Fucini, P, Connell, S.
登録日2020-09-19
公開日2021-07-07
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021
7AFA
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BU of 7afa by Molmil
Bacterial 30S ribosomal subunit assembly complex state F (head domain)
分子名称: 16SrRNA (head domain of the 30S ribosome), 30S ribosomal protein S10, 30S ribosomal protein S13, ...
著者Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Kaminishi, T, Diercks, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S.
登録日2020-09-19
公開日2021-07-07
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021

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