1R59
 
 | | Enterococcus casseliflavus glycerol kinase | | 分子名称: | Glycerol kinase | | 著者 | Yeh, J.I, Charrier, V, Paulo, J, Hou, L, Darbon, E, Claiborne, A, Hol, W.G, Deutscher, J. | | 登録日 | 2003-10-09 | | 公開日 | 2004-10-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of conformation to substrate binding and a mechanism of activation by phosphorylation
Biochemistry, 43, 2004
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4EQX
 | | Crystal Structure of the C43S Mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Edwards, J.S, Wallace, B.D, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EMW
 | | Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor EtVC-CoA | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Edwards, J.S, Wallace, B.D, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-12 | | 公開日 | 2012-10-17 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQR
 | | Crystal structure of the Y361F mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, COENZYME A, Coenzyme A disulfide reductase, ... | | 著者 | Wallace, B.D, Edwards, J.S, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQW
 | | Crystal Structure of the Y361F, Y419F Mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, COENZYME A, Coenzyme A disulfide reductase, ... | | 著者 | Edwards, J.S, Wallace, B.D, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EM3
 | | Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor MeVS-CoA | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Wallace, B.D, Edwards, J.S, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-11 | | 公開日 | 2012-10-17 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.977 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQS
 | | Crystal structure of the Y419F mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, COENZYME A, Coenzyme A disulfide reductase, ... | | 著者 | Wallace, B.D, Edwards, J.S, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EM4
 | | Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Wallace, B.D, Edwards, J.S, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-11 | | 公開日 | 2012-10-17 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.821 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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7M6K
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3CGE
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1JOA
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3CGD
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3CGB
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3CGC
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2H3G
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2E9N
 | | Structure of h-CHK1 complexed with A767085 | | 分子名称: | 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE, Serine/threonine-protein kinase Chk1 | | 著者 | Park, C. | | 登録日 | 2007-01-26 | | 公開日 | 2008-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
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1XUP
 | | ENTEROCOCCUS CASSELIFLAVUS GLYCEROL KINASE COMPLEXED WITH GLYCEROL | | 分子名称: | GLYCEROL, Glycerol kinase | | 著者 | Yeh, J.I, Charrier, V, Paulo, J, Hou, L, Darbon, E, Hol, W.G.J, Deutscher, J. | | 登録日 | 2004-10-26 | | 公開日 | 2004-12-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of Conformation to Substrate Binding and a Mechanism of Activation by Phosphorylation
Biochemistry, 43, 2004
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2E9V
 | | Structure of h-CHK1 complexed with A859017 | | 分子名称: | 18-CHLORO-2-OXO-17-[(PYRIDIN-4-YLMETHYL)AMINO]-2,3,11,12,13,14-HEXAHYDRO-1H,10H-4,8-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECINE-7-CARBONITRILE, Serine/threonine-protein kinase Chk1 | | 著者 | Park, C. | | 登録日 | 2007-01-27 | | 公開日 | 2008-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors
To be Published
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2E9O
 | | Structure of h-CHK1 complexed with AA582939 | | 分子名称: | 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID, Serine/threonine-protein kinase Chk1 | | 著者 | Park, C. | | 登録日 | 2007-01-26 | | 公開日 | 2008-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
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2BC0
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2BCP
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2BC1
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2E9P
 | | Structure of h-CHK1 complexed with A771129 | | 分子名称: | 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA, Serine/threonine-protein kinase Chk1 | | 著者 | Park, C. | | 登録日 | 2007-01-26 | | 公開日 | 2008-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-Based Design, Synthesis and Biological Evaluation of Potent and Selective Macrocyclic Chk1 Inhibitors
To be Published
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2E9U
 | | Structure of h-CHK1 complexed with A780125 | | 分子名称: | 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE, Serine/threonine-protein kinase Chk1 | | 著者 | Park, C. | | 登録日 | 2007-01-27 | | 公開日 | 2008-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors
To be Published
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