2E9V
Structure of h-CHK1 complexed with A859017
Summary for 2E9V
Entry DOI | 10.2210/pdb2e9v/pdb |
Related | 2AYP 2E9N 2E9O 2E9P 2E9U 2FGA 2GHG |
Descriptor | Serine/threonine-protein kinase Chk1, 18-CHLORO-2-OXO-17-[(PYRIDIN-4-YLMETHYL)AMINO]-2,3,11,12,13,14-HEXAHYDRO-1H,10H-4,8-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECINE-7-CARBONITRILE (3 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 62838.96 |
Authors | Park, C. (deposition date: 2007-01-27, release date: 2008-01-29, Last modification date: 2024-03-13) |
Primary citation | Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gwaltney, S.L.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H. Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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