2E9O

Structure of h-CHK1 complexed with AA582939

Summary for 2E9O

Entry DOI	10.2210/pdb2e9o/pdb
Related	2AYP 2E9N 2E9P 2E9U 2E9V 2FGA 2GHG
Descriptor	Serine/threonine-protein kinase Chk1, 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID (3 entities in total)
Functional Keywords	protein-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	31470.24
Authors	Park, C. (deposition date: 2007-01-26, release date: 2008-01-29, Last modification date: 2024-03-13)
Primary citation	Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gu, W.Z.,Gwaltney, S.L.,Judge, R.A.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H. Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg.Med.Chem., 15:2759-2767, 2007 Cited by PubMed: 17287122 DOI: 10.1016/j.bmc.2007.01.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation