2GHG

h-CHK1 complexed with A431994

Summary for 2GHG

Entry DOI	10.2210/pdb2ghg/pdb
Related	2AYP 2FGA
Descriptor	Serine/threonine-protein kinase Chk1, 5-{5-[(S)-2-AMINO-3-(1H-INDOL-3-YL)-PROPOXYL]-PYRIDIN-3-YL}-3-[1-(1H-PYRROL-2-YL)-METH-(Z)-YLIDENE]-1,3-DIHYDRO-INDOL-2-ONE (3 entities in total)
Functional Keywords	protein-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	31544.28
Authors	Park, C. (deposition date: 2006-03-27, release date: 2007-03-27, Last modification date: 2024-02-14)
Primary citation	Zhu, G.D.,Gandhi, V.B.,Gong, J.,Luo, Y.,Liu, X.,Shi, Y.,Guan, R.,Magnone, S.R.,Klinghofer, V.,Johnson, E.F.,Bouska, J.,Shoemaker, A.,Oleksijew, A.,Jarvis, K.,Park, C.,De Jong, R.,Oltersdorf, T.,Li, Q.,Rosenberg, S.H.,Giranda, V.L. Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers. Bioorg.Med.Chem.Lett., 16:3424-3429, 2006 Cited by PubMed: 16644221 DOI: 10.1016/j.bmcl.2006.04.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation