5T97
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![BU of 5t97 by Molmil](/molmil-images/mine/5t97) | ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2 -yl)phenyl]-1,2,3,4- tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid | 分子名称: | (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid, Estrogen receptor | 著者 | Kirby, C.A, Baird, J. | 登録日 | 2016-09-09 | 公開日 | 2017-03-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha + Breast Cancer. J. Med. Chem., 60, 2017
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6RYP
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![BU of 6ryp by Molmil](/molmil-images/mine/6ryp) | Bacterial membrane enzyme structure by the in meso method at 2.3 A resolution | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DI(HYDROXYETHYL)ETHER, Lipoprotein signal peptidase, ... | 著者 | Huang, C.Y, Olatunji, S, Bailey, J, Yu, X, Olieric, V, Wang, M, Caffrey, M. | 登録日 | 2019-06-11 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin. Nat Commun, 11, 2020
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6RYO
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![BU of 6ryo by Molmil](/molmil-images/mine/6ryo) | Bacterial membrane enzyme structure by the in meso method at 1.9 A resolution | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, GLYCEROL, ... | 著者 | Huang, C.Y, Olatunji, S, Bailey, J, Yu, X, Olieric, V, Wang, M, Caffrey, M. | 登録日 | 2019-06-11 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.924 Å) | 主引用文献 | Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin. Nat Commun, 11, 2020
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5DIR
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![BU of 5dir by Molmil](/molmil-images/mine/5dir) | membrane protein at 2.8 Angstroms | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Globomycin, Lipoprotein signal peptidase | 著者 | Vogeley, L, El Arnaout, T, Bailey, J, Boland, C, Caffrey, M. | 登録日 | 2015-09-01 | 公開日 | 2016-03-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin. Science, 351, 2016
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5UOH
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![BU of 5uoh by Molmil](/molmil-images/mine/5uoh) | Crystal Structure of Hip1 (Rv2224c) T466A mutant | 分子名称: | Carboxylesterase A | 著者 | Naffin-Olivos, J.L, Daab, A, White, A, Goldfarb, N, Milne, A.C, Liu, D, Baikovitz, J, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. | 登録日 | 2017-01-31 | 公開日 | 2017-04-12 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.609 Å) | 主引用文献 | Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c). Biochemistry, 56, 2017
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1UU9
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![BU of 1uu9 by Molmil](/molmil-images/mine/1uu9) | Structure of human PDK1 kinase domain in complex with BIM-3 | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ... | 著者 | Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2003-12-16 | 公開日 | 2004-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 Structure, 12, 2004
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1UU7
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![BU of 1uu7 by Molmil](/molmil-images/mine/1uu7) | Structure of human PDK1 kinase domain in complex with BIM-2 | 分子名称: | 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, ... | 著者 | Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2003-12-16 | 公開日 | 2004-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 Structure, 12, 2004
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1UVR
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![BU of 1uvr by Molmil](/molmil-images/mine/1uvr) | Structure of human PDK1 kinase domain in complex with BIM-8 | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ... | 著者 | Komander, D, Garrido-Franco, M, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2004-01-22 | 公開日 | 2004-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 Structure, 12, 2004
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1UU3
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![BU of 1uu3 by Molmil](/molmil-images/mine/1uu3) | Structure of human PDK1 kinase domain in complex with LY333531 | 分子名称: | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, ... | 著者 | Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2003-12-15 | 公開日 | 2004-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 Structure, 12, 2004
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1UU8
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![BU of 1uu8 by Molmil](/molmil-images/mine/1uu8) | Structure of human PDK1 kinase domain in complex with BIM-1 | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ... | 著者 | Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2003-12-16 | 公開日 | 2004-03-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 Structure, 12, 2004
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6DHM
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![BU of 6dhm by Molmil](/molmil-images/mine/6dhm) | Bovine glutamate dehydrogenase complexed with zinc | 分子名称: | GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, ... | 著者 | Smith, T.J. | 登録日 | 2018-05-20 | 公開日 | 2018-07-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
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6DHN
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![BU of 6dhn by Molmil](/molmil-images/mine/6dhn) | Bovine glutamate dehydrogenase complexed with Eu3+ | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Smith, T.J. | 登録日 | 2018-05-20 | 公開日 | 2018-07-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
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5LE0
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![BU of 5le0 by Molmil](/molmil-images/mine/5le0) | |
1RFJ
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![BU of 1rfj by Molmil](/molmil-images/mine/1rfj) | Crystal Structure of Potato Calmodulin PCM6 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, calmodulin | 著者 | Liang, D.C, Yun, C.H, Chang, W.R. | 登録日 | 2003-11-10 | 公開日 | 2004-06-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of potato calmodulin PCM6: the first report of the three-dimensional structure of a plant calmodulin. Acta Crystallogr.,Sect.D, 60, 2004
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6W07
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![BU of 6w07 by Molmil](/molmil-images/mine/6w07) | Bruton's tyrosine kinase in complex with compound 1 | 分子名称: | DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK, ~{N}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2020-02-29 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63, 2020
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6VXQ
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![BU of 6vxq by Molmil](/molmil-images/mine/6vxq) | Bruton's tyrosine kinase in complex with compound 5 | 分子名称: | DIMETHYL SULFOXIDE, N-{[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl}benzamide, Tyrosine-protein kinase BTK | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2020-02-23 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63, 2020
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6W06
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![BU of 6w06 by Molmil](/molmil-images/mine/6w06) | Bruton's tyrosine kinase in complex with compound 6 | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-~{tert}-butyl-~{N}-[[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide, DIMETHYL SULFOXIDE, ... | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2020-02-29 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63, 2020
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6KQU
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![BU of 6kqu by Molmil](/molmil-images/mine/6kqu) | Crystal structure of phospholipase A2 | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hou, S, Xu, T, Liu, J. | 登録日 | 2019-08-18 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Residue Asn21 acts as a switch for calcium binding to modulate the enzymatic activity of human phospholipase A2 group IIE. Biochimie, 176, 2020
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6ILU
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![BU of 6ilu by Molmil](/molmil-images/mine/6ilu) | Endolysin LysPBC5 CBD | 分子名称: | 1,2-ETHANEDIOL, Lysin, SULFATE ION | 著者 | Suh, J.Y, Ryu, K.S, Ryu, S, Lee, K.O, Kong, M.S, Bae, J.W, Kim, I.T. | 登録日 | 2018-10-19 | 公開日 | 2019-07-31 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Structural Basis for Cell-Wall Recognition by Bacteriophage PBC5 Endolysin. Structure, 27, 2019
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7JPJ
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![BU of 7jpj by Molmil](/molmil-images/mine/7jpj) | Crystal Structure of the essential dimeric LYSA from Phaeodactylum tricornutum | 分子名称: | D-LYSINE, Diaminopimelate decarboxylase, SULFATE ION | 著者 | Fedorov, E, Belinski, V.A, Brunson, J.K, Almo, S.C, Dupont, C.L, Ghosh, A. | 登録日 | 2020-08-08 | 公開日 | 2021-06-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | The Phaeodactylum tricornutum diaminopimelate decarboxylase was acquired via horizontal gene transfer from bacteria and displays substrate promiscuity Biorxiv, 2020
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1OM1
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![BU of 1om1 by Molmil](/molmil-images/mine/1om1) | Crystal structure of maize CK2 alpha in complex with IQA | 分子名称: | (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID, Casein kinase II, alpha chain | 著者 | Battistutta, R, De Moliner, E, Zanotti, G. | 登録日 | 2003-02-24 | 公開日 | 2004-02-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). Biochem.J., 374, 2003
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5UGQ
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![BU of 5ugq by Molmil](/molmil-images/mine/5ugq) | Crystal Structure of Hip1 (Rv2224c) | 分子名称: | Carboxylesterase A | 著者 | Naffin-Olivos, J.L, Daab, A, White, A, Goldfarb, N, Milne, A.C, Liu, D, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. | 登録日 | 2017-01-09 | 公開日 | 2017-04-12 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.609 Å) | 主引用文献 | Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c). Biochemistry, 56, 2017
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3FL5
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![BU of 3fl5 by Molmil](/molmil-images/mine/3fl5) | Protein kinase CK2 in complex with the inhibitor Quinalizarin | 分子名称: | 1,2,5,8-tetrahydroxyanthracene-9,10-dione, Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER | 著者 | Mazzorana, M, Franchin, C, Battistutta, R. | 登録日 | 2008-12-18 | 公開日 | 2009-08-18 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 Biochem.J., 421, 2009
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5UNO
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![BU of 5uno by Molmil](/molmil-images/mine/5uno) | Crystal Structure of Hip1 (Rv2224c) | 分子名称: | Carboxylesterase A | 著者 | Naffin-Olivos, J.L, Daab, A, White, A, Goldfarb, N, Milne, A.C, Liu, D, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. | 登録日 | 2017-01-31 | 公開日 | 2017-04-12 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c). Biochemistry, 56, 2017
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3KXH
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![BU of 3kxh by Molmil](/molmil-images/mine/3kxh) | Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor (2-dymethylammino-4,5,6,7-tetrabromobenzoimidazol-1yl-acetic acid (K66) | 分子名称: | Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, [4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazol-1-yl]acetic acid | 著者 | Papinutto, E, Franchin, C, Battistutta, R. | 登録日 | 2009-12-03 | 公開日 | 2010-11-17 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | ATP site-directed inhibitors of protein kinase CK2: an update. Curr Top Med Chem, 11, 2011
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