6TVX
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![BU of 6tvx by Molmil](/molmil-images/mine/6tvx) | Human CD73 (ecto 5'-nucleotidase) in complex with PSB12676 (an AOPCP derivative, compound 9 in paper) in the closed state | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | 著者 | Pippel, J, Strater, N. | 登録日 | 2020-01-10 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63, 2020
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6TVE
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8DEP
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![BU of 8dep by Molmil](/molmil-images/mine/8dep) | Cryo-EM structure of the human reduced folate carrier, apo condition | 分子名称: | Digitonin, Reduced folate transporter,Soluble cytochrome b562 | 著者 | Wright, N.J, Fedor, J.G, Lee, S.-Y. | 登録日 | 2022-06-21 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 609, 2022
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8E4O
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![BU of 8e4o by Molmil](/molmil-images/mine/8e4o) | The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4N
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![BU of 8e4n by Molmil](/molmil-images/mine/8e4n) | The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4L
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![BU of 8e4l by Molmil](/molmil-images/mine/8e4l) | The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | 分子名称: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4Q
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![BU of 8e4q by Molmil](/molmil-images/mine/8e4q) | The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2 | 分子名称: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4P
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![BU of 8e4p by Molmil](/molmil-images/mine/8e4p) | Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | 分子名称: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4M
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![BU of 8e4m by Molmil](/molmil-images/mine/8e4m) | The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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4PD6
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4PD8
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![BU of 4pd8 by Molmil](/molmil-images/mine/4pd8) | Structure of vcCNT-7C8C bound to pyrrolo-cytidine | 分子名称: | 6-methyl-3-(beta-D-ribofuranosyl)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | 著者 | Johnson, Z.L, Lee, S.-Y. | 登録日 | 2014-04-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PB1
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![BU of 4pb1 by Molmil](/molmil-images/mine/4pb1) | Structure of vcCNT-7C8C bound to ribavirin | 分子名称: | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | 著者 | Johnson, Z.L, Lee, S.-Y. | 登録日 | 2014-04-11 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | 主引用文献 | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD5
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4PDA
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![BU of 4pda by Molmil](/molmil-images/mine/4pda) | Structure of vcCNT-7C8C bound to cytidine | 分子名称: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | 著者 | Johnson, Z.L, Lee, S.-Y. | 登録日 | 2014-04-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.608 Å) | 主引用文献 | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD9
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![BU of 4pd9 by Molmil](/molmil-images/mine/4pd9) | Structure of vcCNT-7C8C bound to adenosine | 分子名称: | ADENOSINE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | 著者 | Johnson, Z.L, Lee, S.-Y. | 登録日 | 2014-04-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.096 Å) | 主引用文献 | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PB2
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4PD7
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![BU of 4pd7 by Molmil](/molmil-images/mine/4pd7) | Structure of vcCNT bound to zebularine | 分子名称: | DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ... | 著者 | Johnson, Z.L, Lee, S.-Y. | 登録日 | 2014-04-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.909 Å) | 主引用文献 | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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6NC6
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![BU of 6nc6 by Molmil](/molmil-images/mine/6nc6) | Lipid II flippase MurJ, inward closed conformation | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Lipid II flippase MurJ, ... | 著者 | Kuk, A.C.Y, Lee, S.-Y. | 登録日 | 2018-12-10 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6CSN
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![BU of 6csn by Molmil](/molmil-images/mine/6csn) | Crystal structure of the designed light-gated anion channel iC++ at pH8.5 | 分子名称: | CHLORIDE ION, OLEIC ACID, RETINAL, ... | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | 登録日 | 2018-03-21 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature, 561, 2018
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6NC7
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6CSO
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![BU of 6cso by Molmil](/molmil-images/mine/6cso) | Crystal structure of the designed light-gated anion channel iC++ at pH6.5 | 分子名称: | OLEIC ACID, RETINAL, iC++ | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | 登録日 | 2018-03-21 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature, 561, 2018
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6NC8
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![BU of 6nc8 by Molmil](/molmil-images/mine/6nc8) | Lipid II flippase MurJ, inward occluded conformation | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, PENTAETHYLENE GLYCOL, ... | 著者 | Kuk, A.C.Y, Lee, S.-Y. | 登録日 | 2018-12-11 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6NC9
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![BU of 6nc9 by Molmil](/molmil-images/mine/6nc9) | Lipid II flippase MurJ, outward-facing conformation | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, ... | 著者 | Kuk, A.C.Y, Lee, S.-Y. | 登録日 | 2018-12-11 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Visualizing conformation transitions of the Lipid II flippase MurJ. Nat Commun, 10, 2019
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6NR4
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![BU of 6nr4 by Molmil](/molmil-images/mine/6nr4) | Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium | 分子名称: | Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | 登録日 | 2019-01-22 | 公開日 | 2019-02-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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6NR2
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![BU of 6nr2 by Molmil](/molmil-images/mine/6nr2) | Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2 | 分子名称: | (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | 登録日 | 2019-01-22 | 公開日 | 2019-02-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
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