5EYO
| The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA | 分子名称: | DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max | 著者 | Wang, D, Hashimoto, H, Zhang, X, Cheng, X. | 登録日 | 2015-11-25 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. Nucleic Acids Res., 45, 2017
|
|
8V2F
| Crystal structure of IRAK4 kinase domain with compound 9 | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
|
|
8V1O
| Crystal structure of IRAK4 kinase domain with compound 4 | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
|
|
8V2L
| Crystal structure of IRAK4 kinase domain with compound 8 | 分子名称: | 1,2-ETHANEDIOL, Interleukin-1 receptor-associated kinase 4, N-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
|
|
7M10
| |
5EI9
| Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence I | 分子名称: | DNA (5'-D(*AP*TP*CP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*GP*GP*A)-3'), Histone-lysine N-methyltransferase PRDM9, ... | 著者 | Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X. | 登録日 | 2015-10-29 | 公開日 | 2016-02-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.921 Å) | 主引用文献 | Structural basis for human PRDM9 action at recombination hot spots. Genes Dev., 30, 2016
|
|
5EH2
| Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III | 分子名称: | DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*CP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*G)-3'), Histone-lysine N-methyltransferase PRDM9, ... | 著者 | Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X. | 登録日 | 2015-10-27 | 公開日 | 2016-02-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for human PRDM9 action at recombination hot spots. Genes Dev., 30, 2016
|
|
5EGB
| Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II | 分子名称: | DNA (5'-D(*AP*CP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*GP*G)-3'), Histone-lysine N-methyltransferase PRDM9, ... | 著者 | Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X. | 登録日 | 2015-10-26 | 公開日 | 2016-02-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.977 Å) | 主引用文献 | Structural basis for human PRDM9 action at recombination hot spots. Genes Dev., 30, 2016
|
|
7MHT
| CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX | 分子名称: | 5'-D(P*CP*CP*AP*TP*GP*AP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... | 著者 | O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. | 登録日 | 1998-08-05 | 公開日 | 1998-11-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
|
|
3SWR
| |
5JLE
| Crystal structure of SETD2 bound to SAH | 分子名称: | Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Li, H, Yang, S, Zheng, X. | 登録日 | 2016-04-27 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase Genes Dev., 30, 2016
|
|
5JJY
| Crystal structure of SETD2 bound to histone H3.3 K36M peptide | 分子名称: | Histone H3.3, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Yang, S, Zheng, X, Li, H. | 登録日 | 2016-04-25 | 公開日 | 2016-11-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | 主引用文献 | Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase Genes Dev., 30, 2016
|
|
4N0G
| Crystal Structure of PYL13-PP2CA complex | 分子名称: | Abscisic acid receptor PYL13, MAGNESIUM ION, Protein phosphatase 2C 37, ... | 著者 | Li, W, Wang, L, Sheng, X, Yan, C, Zhou, R, Hang, J, Yin, P, Yan, N. | 登録日 | 2013-10-01 | 公開日 | 2013-11-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.382 Å) | 主引用文献 | Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13 Cell Res., 23, 2013
|
|
8EU3
| Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | 著者 | Hu, Z, Zheng, X, Yang, J. | 登録日 | 2022-10-18 | 公開日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Commun, 14, 2023
|
|
8ETP
| Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | 著者 | Hu, Z, Zheng, X, Yang, J. | 登録日 | 2022-10-17 | 公開日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Commun, 14, 2023
|
|
8EUC
| Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | 著者 | Hu, Z, Zheng, X, Yang, J. | 登録日 | 2022-10-18 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Commun, 14, 2023
|
|
5EG9
| The cap binding site of influenza virus protein PB2 as a drug target | 分子名称: | Polymerase basic protein 2 | 著者 | Severin, C, Rocha de Moura, T, Liu, Y, Li, K, Zheng, X, Luo, M. | 登録日 | 2015-10-26 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The cap-binding site of influenza virus protein PB2 as a drug target. Acta Crystallogr D Struct Biol, 72, 2016
|
|
5EG8
| The cap binding site of influenza virus protein PB2 as a drug target | 分子名称: | Polymerase basic protein 2, THIOCYANATE ION | 著者 | Liu, Y, Zheng, X, Severin, C, Rocha de Moura, T, Li, K, Luo, M. | 登録日 | 2015-10-26 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | The cap-binding site of influenza virus protein PB2 as a drug target. Acta Crystallogr D Struct Biol, 72, 2016
|
|
5EG7
| The cap binding site of influenza virus protein PB2 as a drug target | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, Polymerase basic protein 2 | 著者 | Severin, C, Rocha de Moura, T, Liu, Y, Li, K, Zheng, X, Luo, M. | 登録日 | 2015-10-26 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The cap-binding site of influenza virus protein PB2 as a drug target. Acta Crystallogr D Struct Biol, 72, 2016
|
|
5FN0
| Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180 | 分子名称: | 3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, KYNURENINE 3-MONOOXYGENASE | 著者 | Mole, D.J, Webster, S.P, Uings, I, Zheng, X, Binnie, M, Wilson, K, Hutchinson, J.P, Mirguet, O, Walker, A, Beaufils, B, Ancellin, N, Trottet, L, Beneton, V, Mowat, C.G, Wilkinson, M, Rowland, P, Haslam, C, McBride, A, Homer, N.Z.M, Baily, J.E, Sharp, M.G.F, Garden, O.J, Hughes, J, Howie, S.E.M, Holmes, D, Liddle, J, Iredale, J.P. | 登録日 | 2015-11-10 | 公開日 | 2016-01-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis. Nat.Med. (N.Y.), 22, 2016
|
|
6K8N
| Crystal structure of the Sulfolobus solfataricus topoisomerase III | 分子名称: | ZINC ION, topoisomerase III | 著者 | Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y. | 登録日 | 2019-06-13 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain To Be Published
|
|
6K8O
| Crystal structure of the Sulfolobus solfataricus topoisomerase III in complex with DNA | 分子名称: | DNA (5'-D(*GP*CP*AP*AP*GP*GP*TP*C)-3'), ZINC ION, topoisomerase III | 著者 | Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y. | 登録日 | 2019-06-13 | 公開日 | 2020-06-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain To Be Published
|
|
6MG1
| C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2 Crystal Form | 分子名称: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta, ... | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2018-09-12 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
|
|
6MBK
| SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First P212121 Crystal Form | 分子名称: | 1,2-ETHANEDIOL, Actin peptide, GLYCEROL, ... | 著者 | Horton, J.R, Dai, S, Cheng, X. | 登録日 | 2018-08-30 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019
|
|
6MBL
| SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second P212121 Crystal Form | 分子名称: | 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ... | 著者 | Horton, J.R, Dai, S, Cheng, X. | 登録日 | 2018-08-30 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | 主引用文献 | SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019
|
|