5FN0

Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180

Summary for 5FN0

• Entry DOI: 10.2210/pdb5fn0/pdb
• Descriptor: KYNURENINE 3-MONOOXYGENASE, FLAVIN-ADENINE DINUCLEOTIDE, 3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID, ... (4 entities in total)
• Functional Keywords: oxidoreductase, kmo
• Biological source: PSEUDOMONAS FLUORESCENS
• Total number of polymer chains: 4
• Total formula weight: 207204.57

Authors

Mole, D.J.,Webster, S.P.,Uings, I.,Zheng, X.,Binnie, M.,Wilson, K.,Hutchinson, J.P.,Mirguet, O.,Walker, A.,Beaufils, B.,Ancellin, N.,Trottet, L.,Beneton, V.,Mowat, C.G.,Wilkinson, M.,Rowland, P.,Haslam, C.,McBride, A.,Homer, N.Z.M.,Baily, J.E.,Sharp, M.G.F.,Garden, O.J.,Hughes, J.,Howie, S.E.M.,Holmes, D.,Liddle, J.,Iredale, J.P. (deposition date: 2015-11-10, release date: 2016-01-13, Last modification date: 2019-05-08)

• Primary citation: Mole, D.J.,Webster, S.P.,Uings, I.,Zheng, X.,Binnie, M.,Wilson, K.,Hutchinson, J.P.,Mirguet, O.,Walker, A.,Beaufils, B.,Ancellin, N.,Trottet, L.,Beneton, V.,Mowat, C.G.,Wilkinson, M.,Rowland, P.,Haslam, C.,Mcbride, A.,Homer, N.Z.,Baily, J.E.,Sharp, M.G.,Garden, O.J.,Hughes, J.,Howie, S.E.,Holmes, D.S.,Liddle, J.,Iredale, J.P.; Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.; Nat.Med. (N.Y.), 22:202-, 2016; PubMed: 26752518; DOI: 10.1038/NM.4020

Experimental method

X-RAY DIFFRACTION (3.19 Å)