1AJ8
 
 | | CITRATE SYNTHASE FROM PYROCOCCUS FURIOSUS | | 分子名称: | CITRATE SYNTHASE, CITRIC ACID, COENZYME A | | 著者 | Russell, R.J.M, Ferguson, J.M.C, Hough, D.W, Danson, M.J, Taylor, G.L. | | 登録日 | 1997-05-16 | | 公開日 | 1997-11-19 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structure of citrate synthase from the hyperthermophilic archaeon pyrococcus furiosus at 1.9 A resolution,.
Biochemistry, 36, 1997
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1CE5
 | | BOVINE PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZAMIDINE | | 分子名称: | BENZAMIDINE, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Ota, N, Stroupe, C, Ferreira-Da-Silva, J.M.S, Shah, S.S, Mares-Guia, M, Brunger, A.T. | | 登録日 | 1999-03-16 | | 公開日 | 1999-03-23 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Non-Boltzmann thermodynamic integration (NBTI) for macromolecular systems: relative free energy of binding of trypsin to benzamidine and benzylamine.
Proteins, 37, 1999
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4WD4
 | | Crystal structure of human HO1 H25R | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Caaveiro, J.M.M, Morante, K, Sigala, P, Tsumoto, K. | | 登録日 | 2014-09-06 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis
Biochemistry, 55, 2016
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4D0N
 | | AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA | | 分子名称: | 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. | | 登録日 | 2014-04-29 | | 公開日 | 2014-05-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
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3FZW
 | | Crystal Structure of Ketosteroid Isomerase D40N-D103N from Pseudomonas putida (pKSI) with bound equilenin | | 分子名称: | EQUILENIN, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Caaveiro, J.M.M, Ringe, D, Petsko, G.A. | | 登録日 | 2009-01-26 | | 公開日 | 2009-06-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Hydrogen bond coupling in the ketosteroid isomerase active site.
Biochemistry, 48, 2009
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5GHW
 | | Crystal structure of broad neutralizing antibody 10E8 with long epitope bound | | 分子名称: | Endogenous retrovirus group K member 8 Env polyprotein, FAB 10E8 HEAVY CHAIN, FAB 10E8 LIGHT CHAIN, ... | | 著者 | Caaveiro, J.M.M, Rujas, E, Morante, K, Nieva, J.L, Tsumoto, K. | | 登録日 | 2016-06-21 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface
Sci Rep, 6, 2016
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4D0O
 | | AKAP13 (AKAP-Lbc) DH domain | | 分子名称: | A-KINASE ANCHOR PROTEIN 13 | | 著者 | Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. | | 登録日 | 2014-04-29 | | 公開日 | 2014-05-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
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7OU8
 | | Human O-GlcNAc hydrolase in complex with DNJNAc-thiazolidines | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, O-GlcNAcase BT_4395, ... | | 著者 | Males, A, Davies, G.J, Gonzalez-Cuesta, M, Mellet, C.O, Fernandez, J.M.G, Sidhu, P, Ashmus, R, Busmann, J, Vocadlo, D.J, Foster, L. | | 登録日 | 2021-06-11 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
J.Am.Chem.Soc., 144, 2022
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7OU6
 | | Human O-GlcNAc hydrolase in complex with DNJNAc-thiazolidines | | 分子名称: | Protein O-GlcNAcase, ~{N}-[(3~{Z},6~{S},7~{R},8~{R},8~{a}~{S})-7,8-bis(oxidanyl)-3-(phenylmethyl)imino-1,5,6,7,8,8~{a}-hexahydro-[1,3]thiazolo[3,4-a]pyridin-6-yl]ethanamide | | 著者 | Males, A, Davies, G.J, Gonzalez-Cuesta, M, Mellet, C.O, Fernandez, J.M.G, Sidhu, P, Ashmus, R, Busmann, J, Vocadlo, D.J, Foster, L. | | 登録日 | 2021-06-11 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
J.Am.Chem.Soc., 144, 2022
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9AX8
 | | 70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Mattingly, J.M, Nguyen, H.A, Dunham, C.M. | | 登録日 | 2024-03-06 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural analysis of noncanonical translation initiation complexes.
J.Biol.Chem., 2024
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9G34
 | | The HIV protease inhibitor darunavir binding to the active site of Cryphonectria parasitica endothiapepsin | | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | | 著者 | Falke, S, Senst, J.M, Guenther, S, Meents, A. | | 登録日 | 2024-07-11 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The HIV protease inhibitor darunavir binding to the active site of Cryphonectria
parasitica endothiapepsin
To Be Published
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9FVO
 | | The HIV protease inhibitor amprenavir binding to the active site of Cryphonectria parasitica endothiapepsin | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, Endothiapepsin, ... | | 著者 | Falke, S, Senst, J.M, Guenther, S, Meents, A. | | 登録日 | 2024-06-27 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The HIV protease inhibitor amprenavir binding to the active site of Cryphonectria parasitica endothiapepsin
To Be Published
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9G35
 | | The HIV protease inhibitor lopinavir binding to the active site of Cryphonectria parasitica endothiapepsin | | 分子名称: | 1,2-ETHANEDIOL, Endothiapepsin, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... | | 著者 | Falke, S, Senst, J.M, Guenther, S, Meents, A. | | 登録日 | 2024-07-11 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The HIV protease inhibitor lopinavir binding to the active site of Cryphonectria parasitica endothiapepsin
To Be Published
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9FL3
 | | Crystal structure of IL-17A in complex with compound 26 | | 分子名称: | (~{E})-~{N}-[(~{S})-[4,4-bis(fluoranyl)cyclohexyl]-[7-[(1~{S})-2-methoxy-1-[(4~{S})-2-oxidanylidene-4-(trifluoromethyl)imidazolidin-1-yl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-3-cyclopropyl-2-fluoranyl-prop-2-enamide, Interleukin-17A | | 著者 | Rondeau, J.M, Lehmann, S, Scheufler, C. | | 登録日 | 2024-06-04 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.068 Å) | | 主引用文献 | Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and alpha-Fluoroacrylate Containing IL-17 Inhibitors.
J.Med.Chem., 67, 2024
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8W2J
 | | Human liver phosphofructokinase-1 filament in the T-state conformation | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent 6-phosphofructokinase, ... | | 著者 | Lynch, E.M, Kollman, J.M, Webb, B.A. | | 登録日 | 2024-02-20 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for allosteric regulation of human phosphofructokinase-1.
Nat Commun, 15, 2024
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9BAF
 | | Solution NMR structure of conofurin-Delta | | 分子名称: | Alpha-conotoxin LvIA | | 著者 | Harvey, P.J, Craik, D.J, Hone, A.J, McIntosh, J.M. | | 登録日 | 2024-04-04 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-10-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors.
J.Med.Chem., 67, 2024
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9AX7
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8W2G
 | | Human liver phosphofructokinase-1 in the R-state conformation | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 6-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Lynch, E.M, Kollman, J.M, Webb, B.A. | | 登録日 | 2024-02-20 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for allosteric regulation of human phosphofructokinase-1.
Nat Commun, 15, 2024
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9CG7
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9F6A
 | | EVA71 E096A native particle | | 分子名称: | SPHINGOSINE, VP0, VP1, ... | | 著者 | Kingston, N.J, Stonehouse, N.J, Rowlands, D.J, Hogle, J.M, Filman, D.J, Snowden, J.S.S. | | 登録日 | 2024-04-30 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate.
Plos Pathog., 20, 2024
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8W2H
 | | Human liver phosphofructokinase-1 in the T-state conformation | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent 6-phosphofructokinase, ... | | 著者 | Lynch, E.M, Kollman, J.M, Webb, B.A. | | 登録日 | 2024-02-20 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural basis for allosteric regulation of human phosphofructokinase-1.
Nat Commun, 15, 2024
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9F5S
 | | EVA71 E096A native particle | | 分子名称: | SPHINGOSINE, VP0, VP1, ... | | 著者 | Kingston, N.J, Stonehouse, N.J, Rowlands, D.J, Hogle, J.M, Filman, D.J, Snowden, J.S.S. | | 登録日 | 2024-04-30 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate.
Plos Pathog., 20, 2024
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9CG6
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9EUP
 | | Inhibitor-free outward-open structure of Drosophila dopamine transporter | | 分子名称: | 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... | | 著者 | Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. | | 登録日 | 2024-03-27 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J.Neurochem., 168, 2024
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9FXN
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