9G35

The HIV protease inhibitor lopinavir binding to the active site of Cryphonectria parasitica endothiapepsin

Summary for 9G35

• Entry DOI: 10.2210/pdb9g35/pdb
• Related: 9FVO 9G34
• Descriptor: Endothiapepsin, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, TRIETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: aspartic protease, drug development, inhibitor, x-ray crystallographic screening, chestnut blight fungus, protease model, hydrolase
• Biological source: Cryphonectria parasitica (chestnut blight fungus)
• Total number of polymer chains: 1
• Total formula weight: 35105.42

Authors

Falke, S.,Senst, J.M.,Guenther, S.,Meents, A. (deposition date: 2024-07-11, release date: 2024-07-24, Last modification date: 2024-11-13)

• Primary citation: Falke, S.,Senst, J.M.,Guenther, S.,Meents, A.; The HIV protease inhibitor lopinavir binding to the active site of Cryphonectria parasitica endothiapepsin; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)