9G34

The HIV protease inhibitor darunavir binding to the active site of Cryphonectria parasitica endothiapepsin

Summary for 9G34

• Entry DOI: 10.2210/pdb9g34/pdb
• Related: 9FVO
• Descriptor: Endothiapepsin, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: aspartic protease, drug development, inhibitor, x-ray crystallographic screening, chestnut blight fungus, distinct unit cell, hydrolase
• Biological source: Cryphonectria parasitica (chestnut blight fungus)
• Total number of polymer chains: 2
• Total formula weight: 68987.35

Authors

Falke, S.,Senst, J.M.,Guenther, S.,Meents, A. (deposition date: 2024-07-11, release date: 2024-07-24, Last modification date: 2024-11-13)

• Primary citation: Falke, S.,Senst, J.M.,Guenther, S.,Meents, A.; The HIV protease inhibitor darunavir binding to the active site of Cryphonectria parasitica endothiapepsin; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.3 Å)