7WOI
| Structure of the shaft pilin Spa2 from Corynebacterium glutamicum | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Spa2 | 著者 | Wu, Y.F, Wang, L.T, Huang, Y.Y, Zhong, C, Zhou, J. | 登録日 | 2022-01-21 | 公開日 | 2023-01-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Accelerating the design of pili-enabled living materials using an integrative technological workflow. Nat.Chem.Biol., 2023
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6XNU
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5YUD
| Flagellin derivative in complex with the NLR protein NAIP5 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1e, Phase 2 flagellin,Flagellin | 著者 | Yang, X.R, Yang, F, Wang, W.G, Lin, G.Z. | 登録日 | 2017-11-21 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.28 Å) | 主引用文献 | Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Res., 28, 2018
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8K98
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8K9A
| Cryo-EM structure of DSR2-DSAD1 state 2 | 分子名称: | SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI | 著者 | Zhang, H, Li, Z, Li, X.Z. | 登録日 | 2023-07-31 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Insights into the modulation of bacterial NADase activity by phage proteins. Nat Commun, 15, 2024
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8Y3X
| Cell divisome sPG hydrolysis machinery FtsEX-EnvC | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | 著者 | Zhang, Z, Dong, H, Chen, Y. | 登録日 | 2024-01-29 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structure and activity of the septal peptidoglycan hydrolysis machinery crucial for bacterial cell division. Plos Biol., 22, 2024
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6EB0
| STRUCTURE OF 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE (HPAB), OXYGENASE COMPONENT FROM ESCHERICHIA COLI | 分子名称: | 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit, ACETATE ION | 著者 | Zhou, D, Kandavelu, P, Zhang, H, Wang, B.C, Yan, Y, Rose, J. | 登録日 | 2018-08-03 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli. Sci Rep, 9, 2019
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3H0Y
| Aurora A in complex with a bisanilinopyrimidine | 分子名称: | 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide, SULFATE ION, Serine/threonine-protein kinase 6 | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | 登録日 | 2009-04-10 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52, 2009
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3GYO
| Se-Met Rtt106p | 分子名称: | Histone chaperone RTT106 | 著者 | Liu, Y, Huang, H, Shi, Y, Teng, M. | 登録日 | 2009-04-04 | 公開日 | 2009-12-08 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010
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3GYP
| Rtt106p | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Histone chaperone RTT106 | 著者 | Liu, Y, Huang, H, Shi, Y, Teng, M. | 登録日 | 2009-04-04 | 公開日 | 2009-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | 主引用文献 | Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010
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8IM7
| Human gamma-secretase treated with ganglioside GM1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhou, R, Yang, G, Shi, Y. | 登録日 | 2023-03-06 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease. Adv Sci, 10, 2023
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5M4Y
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3O3K
| Crystal structure of AF1382 from Archaeoglobus fulgidus | 分子名称: | Uncharacterized protein AF_1382 | 著者 | Zhu, J.-Y, Zhao, M, Fu, Z.-Q, Yang, H, Chang, J, Xu, H, Chen, L, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2010-07-24 | 公開日 | 2010-08-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal. Acta Crystallogr.,Sect.D, 68, 2012
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8KCI
| ATP-bound hMRP5 outward-open | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 5, MAGNESIUM ION | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-08-07 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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7N85
| Inner ring spoke from the isolated yeast NPC | 分子名称: | Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ... | 著者 | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | 登録日 | 2021-06-13 | 公開日 | 2022-01-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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7N84
| Double nuclear outer ring from the isolated yeast NPC | 分子名称: | Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ... | 著者 | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | 登録日 | 2021-06-13 | 公開日 | 2022-01-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (11.6 Å) | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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7N9F
| Structure of the in situ yeast NPC | 分子名称: | Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ... | 著者 | Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S. | 登録日 | 2021-06-17 | 公開日 | 2022-01-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (37 Å) | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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5XFN
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3H0Z
| Aurora A in complex with a bisanilinopyrimidine | 分子名称: | 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-N-(2-chlorophenyl)benzamide, Serine/threonine-protein kinase 6 | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | 登録日 | 2009-04-10 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52, 2009
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8XN7
| Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | 分子名称: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Huang, W.X, Liu, R, Ding, K. | 登録日 | 2023-12-29 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269, 2024
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7LV8
| Structure of the Marseillevirus nucleosome | 分子名称: | DNA (123-MER), Histone doublet Beta-Alpha (Alpha), Histone doublet Beta-Alpha (Beta), ... | 著者 | Valencia-Sanchez, M.I, Abini-Agbomson, S, Armache, K.-J. | 登録日 | 2021-02-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The structure of a virus-encoded nucleosome. Nat.Struct.Mol.Biol., 28, 2021
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4LJY
| Crystal structure of RNA splicing effector Prp5 in complex with ADP | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J. | 登録日 | 2013-07-05 | 公開日 | 2013-12-11 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep, 5, 2013
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7E17
| Structure of dimeric uPAR | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor | 著者 | Cai, Y, Huang, M. | 登録日 | 2021-02-01 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Crystal structure and cellular functions of uPAR dimer Nat Commun, 13, 2022
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4P1U
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6AKY
| The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 34 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-3-yl)propyl]cyclohexane-1-carboxamide, C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ... | 著者 | Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2018-09-04 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. J. Med. Chem., 61, 2018
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