6AKY

The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 34

Summary for 6AKY

Entry DOI	10.2210/pdb6aky/pdb
Descriptor	C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywords	g protein-coupled receptor chemokine receptor ccr5 antagonist complex structure, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	44817.87
Authors	Zhu, Y.,Zhao, Q.,Wu, B. (deposition date: 2018-09-04, release date: 2018-10-24, Last modification date: 2023-11-22)
Primary citation	Peng, P.,Chen, H.,Zhu, Y.,Wang, Z.,Li, J.,Luo, R.H.,Wang, J.,Chen, L.,Yang, L.M.,Jiang, H.,Xie, X.,Wu, B.,Zheng, Y.T.,Liu, H. Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. J. Med. Chem., 61:9621-9636, 2018 Cited by PubMed: 30234300 DOI: 10.1021/acs.jmedchem.8b01077 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation