3H0Z

Aurora A in complex with a bisanilinopyrimidine

Summary for 3H0Z

Entry DOI	10.2210/pdb3h0z/pdb
Related	3COH 3H0Y 3H10
Descriptor	Serine/threonine-protein kinase 6, 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-N-(2-chlorophenyl)benzamide (2 entities in total)
Functional Keywords	protein:inhibitor complex aurora-a, cell cycle, serine/threonine, protein kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	3
Total formula weight	94949.34
Authors	Wiesmann, C.,Ultsch, M.H.,Cochran, A.G. (deposition date: 2009-04-10, release date: 2009-07-07, Last modification date: 2024-02-21)
Primary citation	Aliagas-Martin, I.,Burdick, D.,Corson, L.,Dotson, J.,Drummond, J.,Fields, C.,Huang, O.W.,Hunsaker, T.,Kleinheinz, T.,Krueger, E.,Liang, J.,Moffat, J.,Phillips, G.,Pulk, R.,Rawson, T.E.,Ultsch, M.,Walker, L.,Wiesmann, C.,Zhang, B.,Zhu, B.Y.,Cochran, A.G. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52:3300-3307, 2009 Cited by PubMed: 19402633 DOI: 10.1021/jm9000314 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.92 Å)

Structure validation