7WET
| Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela | 分子名称: | (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, Peroxiredoxin-1 | 著者 | Zhang, H, Luo, C. | 登録日 | 2021-12-24 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct Target Ther, 8, 2023
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7XOG
| Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ... | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | 登録日 | 2022-05-01 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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7XOE
| Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | 登録日 | 2022-05-01 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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8IJZ
| anti-VEGF mutant | 分子名称: | anti-VEGF nanobody | 著者 | Qian, F, Zhu, S.Q. | 登録日 | 2023-02-28 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration. Bioeng Transl Med, 8, 2023
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8IJS
| anti-VEGF nanobody mutant | 分子名称: | ZINC ION, anti-VEGF nanobody | 著者 | Qian, F, Zhu, S.Q. | 登録日 | 2023-02-28 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration. Bioeng Transl Med, 8, 2023
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8IIU
| anti-VEGF nanobody | 分子名称: | SULFATE ION, anti-VEGF nanobody | 著者 | Qian, F, Zhu, S.Q. | 登録日 | 2023-02-24 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration. Bioeng Transl Med, 8, 2023
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7CA8
| The crystal structure of COVID-19 main protease in complex with an inhibitor Shikonin | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | 著者 | Zhou, X.L, Zhong, F.L, Lin, C, Li, J, Zhang, J. | 登録日 | 2020-06-08 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Sci Bull (Beijing), 66, 2021
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5KW1
| Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue | 分子名称: | CHLORIDE ION, DNA/RNA (30-MER), Poly(U)-binding-splicing factor PUF60 | 著者 | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | 登録日 | 2016-07-15 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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5KVY
| CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG | 分子名称: | CHLORIDE ION, DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | 著者 | Hsiao, H.-H, Crichlow, G.V, Albright, R.A, Murphy, J.W, Lolis, E.J, Braddock, D.T. | 登録日 | 2016-07-15 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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7XDV
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7XDX
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7XDW
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7XDY
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5KW6
| Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base | 分子名称: | DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | 著者 | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | 登録日 | 2016-07-15 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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7DMN
| Crystal structure of two pericyclases catalyzing [4+2] cycloaddition | 分子名称: | Diels-Alderase fsa2, GLYCEROL | 著者 | Chi, C.B, Wang, Z.D, Liu, T, Zhang, Z.Y, Ma, M. | 登録日 | 2020-12-04 | 公開日 | 2021-10-06 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of Fsa2 and Phm7 Catalyzing [4 + 2] Cycloaddition Reactions with Reverse Stereoselectivities in Equisetin and Phomasetin Biosynthesis. Acs Omega, 6, 2021
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7DMO
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5XRR
| Crystal structure of FUS (54-59) SYSSYG | 分子名称: | RNA-binding protein FUS, ZINC ION | 著者 | Zhao, M, Gui, X, Li, D, Liu, C. | 登録日 | 2017-06-09 | 公開日 | 2018-04-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.503 Å) | 主引用文献 | Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat. Struct. Mol. Biol., 25, 2018
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5Y7L
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5ZGD
| hnRNPA1 reversible amyloid core GFGGNDNFG (residues 209-217) determined by X-ray | 分子名称: | GLY-PHE-GLY-GLY-ASN-ASP-ASN-PHE-GLY | 著者 | Gui, X, Xie, M, Zhao, M, Luo, F, He, J, Li, D, Liu, C. | 登録日 | 2018-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | 主引用文献 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun, 10, 2019
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5ZGL
| hnRNP A1 segment GGGYGGS (residues 234-240) | 分子名称: | 7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1 | 著者 | Xie, M, Luo, F, Gui, X, Zhao, M, He, J, Li, D, Liu, C. | 登録日 | 2018-03-09 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun, 10, 2019
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5ZMA
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7XZ5
| GPR119-Gs-LPC complex | 分子名称: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-06-02 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XZ6
| GPR119-Gs-APD668 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-06-02 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7UAK
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7DSY
| Crystal Structure of RNase L in complex with KM05073 | 分子名称: | 1-chloranyl-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, PHOSPHATE ION, ... | 著者 | Tang, J, Huang, H. | 登録日 | 2021-01-03 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.651 Å) | 主引用文献 | Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem., 65, 2022
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